E
Elwin Janssen
Researcher at VU University Amsterdam
Publications - 34
Citations - 962
Elwin Janssen is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Enantioselective synthesis & Isocyanide. The author has an hindex of 15, co-authored 32 publications receiving 868 citations.
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Journal ArticleDOI
A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions
Anass Znabet,Marloes Polak,Elwin Janssen,Frans J. J. de Kanter,Nicholas J. Turner,Romano V. A. Orru,Eelco Ruijter +6 more
TL;DR: A very short and efficient synthesis of the important drug candidate telaprevir, featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps, is presented.
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The efficient one-pot reaction of up to eight components by the union of multicomponent reactions.
Niels Elders,Dion van der Born,Loes J. D. Hendrickx,Brian J. J. Timmer,Alrik Krause,Elwin Janssen,Frans J. J. de Kanter,Eelco Ruijter,Romano V. A. Orru +8 more
TL;DR: A novel approach is reported that combines two or more MCRs in one pot to achieve higher-order M CRs with unprecedented possibilities for complexity generation and diversification.
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Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion.
Tjoestil Vlaar,Eelco Ruijter,Anass Znabet,Elwin Janssen,Frans J. J. de Kanter,Bert U. W. Maes,Romano V. A. Orru +6 more
TL;DR: Palladium-catalyzed cross-coupling of a wide range of substituted o-(pseudo)halobenzoates and hydrazines with isocyanide insertion followed by lactamization efficiently affords 4-aminophthalazin-1(2H)-ones that are difficult to obtain regioselectively by classical methods.
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Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines.
Gitte Van Baelen,Sander Kuijer,Lukáš Rýček,Sergey Sergeyev,Elwin Janssen,Frans J. J. de Kanter,Bert U. W. Maes,Eelco Ruijter,Romano V. A. Orru +8 more
TL;DR: Various substituents are tolerated on the amidine and the isocyanide, providing efficient access to a broad range of diversely substituted 4-aminoquinazolines of significant pharmaceutical interest.
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Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet–Spengler-type cyclization sequence
Anass Znabet,Job Zonneveld,Elwin Janssen,Frans J. J. de Kanter,Madelaine Helliwell,Nicholas J. Turner,Eelco Ruijter,Romano V. A. Orru +7 more
TL;DR: This article combined the biocatalytic desymmetrization of 3,4cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds.