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Elysia A Masters
Researcher at University of Rochester Medical Center
Publications - 18
Citations - 659
Elysia A Masters is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Staphylococcus aureus & Osteomyelitis. The author has an hindex of 6, co-authored 14 publications receiving 246 citations. Previous affiliations of Elysia A Masters include University of Rochester.
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Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".
Elysia A Masters,Ryan P. Trombetta,Karen L. de Mesy Bentley,Brendan F. Boyce,Ann L. Gill,Steven R. Gill,Kohei Nishitani,Kohei Nishitani,Masahiro Ishikawa,Masahiro Ishikawa,Yugo Morita,Yugo Morita,Hiromu Ito,Sheila N. Bello-Irizarry,Mark J. Ninomiya,James D. Brodell,Charles C. Lee,Stephanie P. Hao,Irvin Oh,Chao Xie,Hani A. Awad,John L. Daiss,John R. Owen,Stephen L. Kates,Edward M. Schwarz,Gowrishankar Muthukrishnan +25 more
TL;DR: Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network of cortical bone.
Journal ArticleDOI
Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond.
Benjamin F. Ricciardi,Gowrishankar Muthukrishnan,Elysia A Masters,Mark J. Ninomiya,Charles C. Lee,Edward M. Schwarz +5 more
TL;DR: Challenges remain given the diverse mechanisms developed by S. aureus to alter the host immune responses, and further understanding of these processes should provide novel therapeutic mechanisms to enhance eradication after PJI.
Journal ArticleDOI
Skeletal infections: microbial pathogenesis, immunity and clinical management
Elysia A Masters,Benjamin F. Ricciardi,Karen L. de Mesy Bentley,Thomas Fintan Moriarty,Edward M. Schwarz,Gowrishankar Muthukrishnan +5 more
TL;DR: In this paper , the authors explore the microbial pathogenesis, immunity and clinical management of bone infections, including osteomyelitis classification and strategies to treat skeletal infections with emerging technologies that could translate to the clinic in the future.
Journal ArticleDOI
Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis.
TL;DR: The unique pathogenic mechanisms utilized by S. aureus that enable it to cause incurable osteomyelitis are reviewed to provide new targets for antibiotics and immunotherapies.
Journal ArticleDOI
Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice.
Elysia A Masters,Karen L. de Mesy Bentley,Ann L. Gill,Stephanie P. Hao,Chad A. Galloway,Alec T. Salminen,Diamond R. Guy,James L. McGrath,Hani A. Awad,Steven R. Gill,Edward M. Schwarz +10 more
TL;DR: Results demonstrate that PBP4 is required for S. aureus colonization of the O LCN and suggest that inhibitors may be synergistic with standard of care antibiotics ineffective against bacteria within the OLCN.