E
Emiko Miyahara
Researcher at Kagoshima University
Publications - 8
Citations - 161
Emiko Miyahara is an academic researcher from Kagoshima University. The author has contributed to research in topics: Acrolein & Cardiotoxicity. The author has an hindex of 6, co-authored 8 publications receiving 127 citations.
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Journal ArticleDOI
Role of metabolites of cyclophosphamide in cardiotoxicity
TL;DR: By inhibiting ROS generation, increasing ALDH activity and decreasing the presence of acrolein, NAC has the potential to prevent CY-induced cardiotoxicity.
Journal ArticleDOI
Mechanisms of Fatal Cardiotoxicity following High-Dose Cyclophosphamide Therapy and a Method for Its Prevention.
Takuro Nishikawa,Emiko Miyahara,Koichiro Kurauchi,Erika Watanabe,Kazuro Ikawa,Kousuke Asaba,Takayuki Tanabe,Yasuhiro Okamoto,Yoshifumi Kawano +8 more
TL;DR: Any competitive metabolic processing of CY that reduces its transformation to acrolein is likely to be an important mechanism for preventing cardiotoxicity.
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Environmental mutagens may be implicated in the emergence of drug-resistant microorganisms.
Emiko Miyahara,Makiko Nishie,Shota Takumi,Hiroaki Miyanohara,Junichiro Nishi,Kiyotaka Yoshiie,Hiroshi Oda,Minoru Takeuchi,Masaharu Komatsu,Kohji Aoyama,Masahisa Horiuchi,Toru Takeuchi +11 more
TL;DR: Findings show that environmental mutagens, and an anticancer drug, are capable of inducing drug-resistant P. aeruginosa similar to strains found in clinical settings.
Journal ArticleDOI
Benzene Metabolite 1,2,4-Benzenetriol Induces Halogenated DNA and Tyrosines Representing Halogenative Stress in the HL-60 Human Myeloid Cell Line
Takuro Nishikawa,Emiko Miyahara,Masahisa Horiuchi,Kimiko Izumo,Yasuhiro Okamoto,Yoshichika Kawai,Yoshifumi Kawano,Toru Takeuchi +7 more
TL;DR: Halogenative stress may account for benzene-induced bone marrow disorders and myeloid leukemia and this H2O2 is metabolized to HOCl by MPO, and this HOCl results in possibly cytotoxic binding of chlorine to DNA.
Journal ArticleDOI
Benzene induces cytotoxicity without metabolic activation.
Takuro Nishikawa,Kimiko Izumo,Emiko Miyahara,Masahisa Horiuchi,Yasuhiro Okamoto,Yoshifumi Kawano,Toru Takeuchi +6 more
TL;DR: Benzene Induces Cytotoxicity without Metabolic Activation: Takuro Nishikawa, et al.