E
Emilia Naydenova
Researcher at Sofia University
Publications - 58
Citations - 577
Emilia Naydenova is an academic researcher from Sofia University. The author has contributed to research in topics: Biological activity & Hydantoin. The author has an hindex of 13, co-authored 52 publications receiving 515 citations. Previous affiliations of Emilia Naydenova include Centre national de la recherche scientifique.
Papers
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Recent synthesis of aminophosphonic acids as potential biological importance
TL;DR: This review summarizes recent developments in the synthesis, characterization and biological activity of α-aminophosphonic acid and N-analogues and indicates one of the potential future developments is peptide hydrolysis.
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Novel N-(phosphonomethyl) glycine derivatives: Design, characterization and biological activity
Emilia Naydenova,Petar Todorov,M. Topashka-Ancheva,Georgi Momekov,Tsvetelina Z. Yordanova,Konstantinov Spiro M,Kolio Troev +6 more
TL;DR: The 8- and 12-membered cyclic analogs proved superior to the remaining compounds and were found to trigger apoptotic cell death in DOHH-2 cells.
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Aminoderivatives of cycloalkanespirohydantoins: synthesis and biological activity.
Emilia Naydenova,Nevena Pencheva,Julita Popova,Neyko Stoyanov,Maria Lazarova,Boris V. Aleksiev +5 more
TL;DR: These compounds failed to induce either anticonvulsive effects in the central nervous system or inhibitory effects on cholinergic contractions in the enteric nervous system, but exerted well pronounced, atropinsensitive, contractile effects on the guinea-pig ileum longitudinal muscle preparations.
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Synthesis and biological activity of novel small peptides with aminophosphonates moiety as NOP receptor ligands
TL;DR: The data showed that substitution of Arg at position 1 with aminophosphonates moiety decreased significantly the affinity of ligands to the NOP receptor, and the enlargement of the cycle diminished both the activity and the selectivity for NOP-receptor.
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Synthesis, cytotoxicity and clastogenicity of novel α-aminophosphonic acids
TL;DR: In this paper, an alpha-ethyl-N-(phosphonomethyl) glycine was synthesized and characterized by NMR and FAB spectroscopy, and the cytotoxicity, clastogenic and antiproliferative effect of 3-ethyl 2-hydroxyl-2-oxo-1, 4, 2-oxazaphosphorinane and glyphosate isopropylammonium salt were tested.