Journal ArticleDOI
Recent synthesis of aminophosphonic acids as potential biological importance
TLDR
This review summarizes recent developments in the synthesis, characterization and biological activity of α-aminophosphonic acid and N-analogues and indicates one of the potential future developments is peptide hydrolysis.Abstract:
Aminophosphonic acids are an important group of medicinal compounds, and their synthesis has been a focus of considerable attention in synthetic organic chemistry as well as medicinal chemistry. Although the phosphonic and carboxylic acid groups differ considerably with respect to shape, size, and acidity, α-aminophosphonic acids are considered to be structural analogues of the corresponding amino acids and the transition state mimics peptide hydrolysis. This review summarizes recent developments in the synthesis, characterization and biological activity of α-aminophosphonic acid and N-analogues. An account of both uses will be presented, emphasizing one of the potential future developments, and some implications in medicinal chemistry are also disclosed. In addition, a brief account on the characterization of N-(phosphonomethyl) glycine derivatives will be presented.read more
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Stimuli-Responsive Therapeutic Metallodrugs.
TL;DR: This review presents a comprehensive and up-to-date overview on the therapeutic stimuli-responsive metallodrugs that have appeared in the past two decades, where stimuli such as redox, pH, enzyme, light, temperature, and so forth were involved.
Journal ArticleDOI
Selected organophosphorus compounds with biological activity. Applications in medicine
TL;DR: An overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity can be found in this article, where the authors outline the findings of a literature review on OPs, including anticancer and antiviral agents, bisphosphonates, phosphorus analogues of amino acids and peptides.
Journal ArticleDOI
Iron-Catalyzed Oxidative Mono- and Bis-Phosphonation of N,N-Dialkylanilines
TL;DR: In this paper, the X-ray crystal structure of N-(5,5-dimethyl-2-oxo-2λ 5 -[1,3,2]dioxaphosphinan-2,yl-methyl)-N-methyl-p-toluidine was determined.
Journal ArticleDOI
Asymmetric Synthesis of Quaternary α‐Amino Acids and Their Phosphonate Analogues
TL;DR: This Focus Review provides a summary of recent approaches to catalytic asymmetric synthesis of quaternary α-amino acids and α-aminophosphonates.
Journal ArticleDOI
λ5-Phosphorus-Containing α-Diazo Compounds: A Valuable Tool for Accessing Phosphorus-Functionalized Molecules
TL;DR: This Review aims to demonstrate the ongoing utility of PCDCs in the modern preparation of different classes of phosphorus-containing compounds, phosphonates, in particular and to address the lack of precedent collective papers.
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Book
Monoclonal Antibodies: Principles and Practice
TL;DR: The present volume has been comprehensively updated to cover recent rapid advances, particularly with respect to the applications of molecular biology, the use of antibodies in closing and heterologous expression of genes, immunohistology and phage display libraries.
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Glyphosate: A Unique Global Herbicide
TL;DR: A comprehensive review of glyphosate's history, properties, chemistry, biology, formulation, technology, enzymology, and structure/activity relationship can be found in this article, where the authors discuss glyphosate's unique environmental properties, broad range of application, soil inactivity, soil and plant metabolism, low toxicity and uptake and transport in plants.
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Differential effects of glyphosate and roundup on human placental cells and aromatase.
TL;DR: It is shown that glyphosate is toxic to human placental JEG3 cells within 18 hr with concentrations lower than those found with agricultural use, and this effect increases with concentration and time, and the presence of Roundup adjuvants enhances glyphosate bioavailability and/or bioaccumulation.