Emilly Schlee Villodre

TL;DR: The photochemical basis of Acridine Orange (AO) is described and its usefulness as a probe for autophagy quantification is found and it is found that considering the red-to-green fluorescence intensity ratio of AO gives the best correlation with other autophagic assays.

TL;DR: The crosstalk among autophagy, cell cycle and apoptosis, together with the biology of gCSCs, has to be considered in tailoring pharmacological interventions aimed to reduce glioma growth using compounds with multiple targets such as Rsv.

TL;DR: Using the Cancer Genome Atlas database, it was showed that OCT4 expression correlated negatively with patient survival in pancreatic cancer, indicating the biological complexity of this transcription factor in biology and, therefore, in cancer.

TL;DR: The differential expression of purinergic receptor in tumor spheres when compared to adherent cells and the effect of ATP in reducing tumor spheres suggest that the purInergic system affects CSC biology and that ATP may be a potential agonist for differentiation therapy.

TL;DR: RNA interference of the P2X7 receptor drastically reduced ATP‐induced cell death, suggesting that this receptor is necessary for this effect, and shed light on the importance of ATP‐ induced cell death in glioma development.