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Emily Florine
Researcher at Massachusetts Institute of Technology
Publications - 8
Citations - 200
Emily Florine is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Cartilage & Stromal cell. The author has an hindex of 4, co-authored 8 publications receiving 144 citations.
Papers
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Journal ArticleDOI
Effects of Insulin-like Growth Factor-1 and Dexamethasone on Cytokine-Challenged Cartilage: Relevance to Post Traumatic Osteoarthritis
Yang Li,Yang Wang,S. Chubinskaya,Birgit Schoeberl,Emily Florine,Paul W. Kopesky,Alan J. Grodzinsky +6 more
TL;DR: In this paper, the combined use of insulin-like growth factor-1 (IGF-1) and dexamethasone (Dex) was studied to block the multiple degradative effects of cytokine challenge to articular cartilage.
Journal ArticleDOI
Effects of Dexamethasone on Mesenchymal Stromal Cell Chondrogenesis and Aggrecanase Activity: Comparison of Agarose and Self-Assembling Peptide Scaffolds.
Emily Florine,Rachel E. Miller,Ryan M. Porter,Christopher H. Evans,Bodo Kurz,Alan J. Grodzinsky +5 more
TL;DR: The effects of Dex on matrix production are dependent on cell source and hydrogel identity, and this is the first report of Dex reducing aggrecanase activity in a tissue engineering culture system.
Journal ArticleDOI
Delivering Heparin-Binding Insulin-Like Growth Factor 1 with Self-Assembling Peptide Hydrogels
Emily Florine,Rachel E. Miller,Paul Liebesny,Keri A. Mroszczyk,Richard T. Lee,Parth Patwari,Alan J. Grodzinsky +6 more
TL;DR: Delivery of HB-IGF-1 to focal defects in cartilage using self-assembling peptide hydrogels is a promising technique that could aid cartilage repair via enhanced matrix production and integration with native tissue.
Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis
Susan Chubinskaya,Birgit Schoeberl,Emily Florine,Paul W. Kopesky,Yang Li,Alan J. Grodzinsky,Yang Wang +6 more
TL;DR: The findings suggest that the combination of IGF-1 and Dex has greater beneficial effects than either molecule alone in preventing cytokine-mediated cartilage degradation in adult human and young bovine cartilage.
Patent
Cartilage-binding fusion proteins
Emily Florine,Dmitri B. Kirpotin,Paul W. Kopesky,Alexey Lugovskoy,Rachel Rennard,Birgit Schoeberl +5 more
TL;DR: In this article, the authors present fusion proteins comprising a first domain that specifically binds to the extracellular domain of a growth factor receptor, and a second domain specifically binding to a cartilage matrix component, and pharmaceutical composition comprising these fusion proteins.