Emily R. Schultz

TL;DR: A new primer design strategy for PCR amplification of unknown targets that are related to multiply-aligned protein sequences that consists of a short 3' degenerate core region and a longer 5' consensus clamp region, which demonstrates the practical utility of this hybrid primer method.

TL;DR: Estimation of template dilution studies in the presence of human carrier DNA demonstrated that six human herpesviruses could be detected at levels at or below 100 genome equivalents per 100 ng of carrier DNA, suggesting that consensus primer PCR targeted to herpesviral DNA polymerase may prove to be useful in the detection and identification of known herpesvirus in clinical samples and the initial characterization of new herpesViral genomes.

TL;DR: Examination of 86 brain specimens by PCR demonstrated that HHV-6 was present in > 70% of MS cases and controls and is thus a commensal virus of the human brain, suggesting an association of HHv-6 with the etiology or pathogenesis of MS.

TL;DR: DNA sequence evidence for two new herpesviruses closely related to KSHV from RF tissues of two macaque species, Macaca nemestrina and Macaca mulatta suggest a new group within the subfamily Gammaherpesvirinae whose members are implicated in the pathogenesis of KS and KS-like neoplasms in different primate species.

TL;DR: The findings raise the possibility of the existence of another human KSHV-like herpesvirus belonging to the second rhadinovirus lineage in Old World primates.