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Emma Sinclair
Researcher at University of Surrey
Publications - 4
Citations - 42
Emma Sinclair is an academic researcher from University of Surrey. The author has contributed to research in topics: Antibody & Somatic hypermutation. The author has an hindex of 2, co-authored 3 publications receiving 27 citations.
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Journal ArticleDOI
Immunoglobulin gene analysis as a tool for investigating human immune responses
TL;DR: The juxtaposition of lymphocyte development and numerical evaluation of immune repertoireires has resulted in the growth of a new sub‐speciality in immunology where immunologists and computer scientists/physicists collaborate to assess immune repertoires and develop models of immune action.
Book ChapterDOI
Age-Related Changes in B Cells Relevant to Vaccine Responses.
TL;DR: Older people have reduced immune responses to infection and vaccination, and changes in antibody repertoire are seen, including greater levels of IgG2 in older people and altered IgG1 IGHV gene usage.
Posted ContentDOI
Pandemic, epidemic, endemic: B cell repertoire analysis reveals unique anti-viral responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus
Alexander J. Stewart,Emma Sinclair,Ilaria Serangeli,Nora Kasar,Katherine Longman,Cecile Frampas,Holly-May Lewis,Catia Costa,David Kipling,Peter J. M. Openshaw,Christopher Chiu,J Kenneth Baillie,Janet T Scott,Malcolm G Semple,Melanie J. Bailey,Deborah K. Dunn-Walters +15 more
TL;DR: In this paper, compositional and lineage analysis of long read IGH repertoire sequencing, combining examples of pandemic, epidemic and endemic viral infections with control and vaccination samples, demonstrates general responses including increased use of IGHV4-39 in both EBOV and COVID-19 infection cohorts.
Journal ArticleDOI
Chickens, more than humans, focus the diversity of their immunoglobulin genes on the complementarity-determining region but utilise amino acids, indicative of a more cross-reactive antibody repertoire
Jessica Mallaby,Joseph Chi Fung Ng,A. Renee Stewart,Emma Sinclair,Deborah K. Dunn-Walters,Uri Hershberg +5 more
TL;DR: In this article , the authors compared the diversity characteristics of immunoglobulin genes from domestic chickens to those from humans and found that chickens exhibited lower amino acid diversity in comparison to the human immunoglobalulin genes, especially outside of the complementarity determining region (CDR).