D
Deborah K. Dunn-Walters
Researcher at University of Surrey
Publications - 118
Citations - 4953
Deborah K. Dunn-Walters is an academic researcher from University of Surrey. The author has contributed to research in topics: Somatic hypermutation & Antibody. The author has an hindex of 38, co-authored 111 publications receiving 4285 citations. Previous affiliations of Deborah K. Dunn-Walters include King's College London & Guy's Hospital.
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Journal ArticleDOI
B-cell diversity decreases in old age and is correlated with poor health status
Kate Gibson,Yu-Chang Wu,Yvonne Barnett,Orla Duggan,Robert Vaughan,E. Kondeatis,Bengt-Olof Nilsson,Anders Wikby,David Glyn Kipling,Deborah K. Dunn-Walters +9 more
TL;DR: It is concluded that B‐cell diversity can decrease dramatically with age and may have important implications for the immune health of older people.
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Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells.
TL;DR: These studies provide the first evidence that the human splenic MGZ is a reservoir of memory B cells.
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Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
Zahra Sabouri,Peter R. Schofield,Keisuke Horikawa,Emily Spierings,David Glyn Kipling,Katrina L. Randall,David B. Langley,Brendan Roome,Rodrigo Vazquez-Lombardi,Romain Rouet,Jana R. Hermes,Tyani D. Chan,Robert Brink,Deborah K. Dunn-Walters,Daniel Christ,Christopher C. Goodnow +15 more
TL;DR: The experiments here provide evidence for a mechanism to acquire self/non-self discrimination by somatic mutation away from self-reactivity, and reveal how varying the efficiency of N-glycosylation provides a mechanisms to modulate antibody avidity.
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B cells and aging: molecules and mechanisms
Michael P. Cancro,Yi Hao,Jean L. Scholz,Richard L. Riley,Daniela Frasca,Deborah K. Dunn-Walters,Bonnie B. Blomberg +6 more
TL;DR: These findings set the stage for integrated analyses of how age-related changes at the molecular, cellular and population levels interact to yield the overall aging phenotype.
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Human marginal-zone B cells
TL;DR: Marginal-zone B cells are likely to be the first B cells in lymphoid tissue to encounter antigen, but this does not reflect a specific function, since the population appears to be functionally heterogeneous.