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Emyr Lloyd-Evans
Researcher at Cardiff University
Publications - 63
Citations - 3632
Emyr Lloyd-Evans is an academic researcher from Cardiff University. The author has contributed to research in topics: Lysosomal storage disease & Biology. The author has an hindex of 22, co-authored 48 publications receiving 3159 citations. Previous affiliations of Emyr Lloyd-Evans include National Institutes of Health & University of Oxford.
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Journal ArticleDOI
Visualisation of cholesterol and ganglioside GM1 in zebrafish models of Niemann-Pick type C disease and Smith-Lemli-Opitz syndrome using light sheet microscopy
Sophie R Cook,Cerys Bladen,Johanna Smith,Emily Maguire,Jordan Copner,Gareth D Fenn,Kim Wager,Helen Waller-Evans,Helen Waller-Evans,Emyr Lloyd-Evans +9 more
TL;DR: It is found that zebrafish accurately model lysosomal storage and disease-specific phenotypes in both diseases, and the immense potential that light sheet microscopy has in aiding the resolution of studies involving lysOSomal and lipid disorders is demonstrated.
Journal ArticleDOI
62. Abnormal lysosomal calcium homeostasis in mucolipidosis type IV
Posted ContentDOI
Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX
Lainey J Williamson,M. Galchenkova,Hannah L Best,Richard J. Braun,Anna Munke,Salah Awel,Gisel Pena,Juraj Knoska,Robin Schubert,Katerina Doerner,Emyr Lloyd-Evans,Mark Young,Joana Valério,Marco Kloos,Marcin Sikorski,Grant Mills,Johan Bieleki,Henry Kirkwood,Chan Kim,R. De Wijn,Kristina Lorenzen,Paulrajpillai Lourdu Xavier,Aida Rahmani,Luca Gelisio,Oleksandr Yefanov,Adrian P. Mancuso,Henry N. Chapman,Neil Crickmore,Pierre J. Rizkallah,Colin Berry,D. Oberthur +30 more
TL;DR: The Tpp49Aa1 structure sheds light on natural crystallisation and, along with cell-based assays broadens the understanding of this two-component system.
Journal ArticleDOI
61. Smith-Lemli-Opitz syndrome: A closet lysosomal storage disease hiding within an inheritable metabolic disorder of cholesterol biosynthesis
Journal ArticleDOI
The Crystal Structure of Bacillus thuringiensis Tpp80Aa1 and Its Interaction with Galactose-Containing Glycolipids
Hannah L Best,Lainey J Williamson,Magdalena Lipka-Lloyd,Helen Waller-Evans,Emyr Lloyd-Evans,Pierre J. Rizkallah,Colin Berry +6 more
TL;DR: The first crystal structure of Tpp80Aa1 at a resolution of 1.8 Å was reported in this article , which showed Tpp 80Aa 1 consists of two domains: an N-terminal β-trefoil domain resembling a ricin B lectin and a C-terminally putative pore-forming domain sharing structural similarity with the aerolysin family.