A comprehensive review on the biological interest of quinoline and its derivatives.

Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

Quinolines are a predominant class of nitrogen containing heterocycles with wide applications in the medical and industrial fields. Owing to their significant importance, numerous synthetic protocols have emerged in the past two centuries. Metal-free synthesis of quinolines has recently gained attention in view of toxic metal-free druggable quinoline synthesis. In this context, this review focuses on the recent advances in the metal-free synthesis of quinolines and covers all the reports from 2016–2020.

Recent advances and prospects in the metal-free synthesis of quinolines.

Recent contributions of quinolines to antimalarial and anticancer drug discovery research.

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

Recently, quinoline has become an essential heterocyclic compound due to its versatile applications in the fields of industrial and synthetic organic chemistry. It is a vital scaffold for leads in drug discovery and plays a major role in the field of medicinal chemistry. Nowadays there are plenty of articles reporting syntheses of the main scaffold and its functionalization for biological and pharmaceutical activities. So far, a wide range of synthesis protocols have been reported in the literature for the construction of this scaffold. For example, Gould–Jacob, Friedlander, Pfitzinger, Skraup, Doebner–von Miller and Conrad–Limpach are well-known classical synthesis protocols used up to now for the construction of the principal quinoline scaffold. Transition metal catalysed reactions, metal-free ionic liquid mediated reactions, ultrasound irradiation reactions and green reaction protocols are also useful for the construction and functionalization of this compound. The main part of this review focuses on and highlights the above-mentioned synthesis procedures and findings to tackle the drawbacks of the syntheses and side effects on the environment. Furthermore, various selected quinolines and derivatives with potential biological and pharmaceutical activities will be presented.

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Endale Mulugeta

Papers

Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review