E
Eng M. Tan
Researcher at Scripps Research Institute
Publications - 71
Citations - 30760
Eng M. Tan is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Antigen & Autoantibody. The author has an hindex of 47, co-authored 71 publications receiving 30110 citations. Previous affiliations of Eng M. Tan include University of Pittsburgh & University of Vermont.
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Journal Article
The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties.
TL;DR: Observations demonstrate for the first time that an environmental toxin can alter the physicochemical properties of an autoantigen and may help to explain the antigenic specificity of mercury-induced murine autoimmunity.
Journal Article
Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/scleroderma overlap syndromes.
TL;DR: Evidence suggests that the PM-Scl antigen complex may be related to a preribosomal particle, suggesting that the antigen is highly conserved.
Journal ArticleDOI
Human autoantibodies: probes for nucleolus structure and function.
TL;DR: Experimental evidence suggests that naturally occurring antibodies in the form of nucleolar autoantigens could be helpful tools in further studying nucleolus structure and functions as well as molecular mechanisms involved in ribosome biogenesis.
Journal ArticleDOI
Immunolocalization of 7-2-ribonucleoprotein in the granular component of the nucleolus.
TL;DR: The immunolocalization data suggest that 7-2-ribonucleoprotein may be involved in stages of ribosome biogenesis which take place in the granular component of the nucleolus, i.e., assembly, maturation, and/or transport of preribosomes.
Journal Article
Anti-fibrillarin autoantibodies in mercury-treated mice.
TL;DR: The present animal model may be valuable for studies of the immunological aberrations which are likely to induce this autoimmune response and the presence of serum autoantibodies reacting with the 10-15 kD proteins correlated with significantly increased titres of anti-histone antibodies of the IgG class in ELISA.