K
Kenneth Michael Pollard
Researcher at Scripps Research Institute
Publications - 56
Citations - 3119
Kenneth Michael Pollard is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Autoimmunity & Autoantibody. The author has an hindex of 28, co-authored 55 publications receiving 2900 citations. Previous affiliations of Kenneth Michael Pollard include Scripps Health & Royal North Shore Hospital.
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Journal ArticleDOI
Silica, Silicosis, and Autoimmunity
TL;DR: The findings from human and animal model studies are consistent with an autoimmune pathogenesis that begins with activation of the innate immune system leading to proinflammatory cytokine production, pulmonary inflammation leading to activation of adaptive immunity, breaking of tolerance, and autoantibodies and tissue damage.
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Monoclonal autoantibody from a (New Zealand black x New Zealand white)F1 mouse and some human scleroderma sera target an Mr 34,000 nucleolar protein of the U3 RNP particle.
G. Reimer,G. Reimer,Kenneth Michael Pollard,C. A. Penning,Robert L. Ochs,Michael A. Lischwe,Harris Busch,E. M. Tan,E. M. Tan,E. M. Tan +9 more
TL;DR: The staining pattern produced by antibody 72B9 in different cell substrates was identical with those obtained by scleroderma antibodies reactive with a basic nucleolar protein of Mr 34,000, which is associated with the U3 RNP particle.
Journal Article
Interferon-γ and Systemic Autoimmunity
TL;DR: The multifaceted nature of IFN-γ in adaptive immunity identifies numerous possible therapeutic targets that, because of the essential contribution of IFn-γ to systemic autoimmunity, have the potential for producing benefits.
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Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis
Frank C. Arnett,John D. Reveille,Rose Goldstein,Kenneth Michael Pollard,Leaird K,Edwin A. Smith,E C LeRoy,Marvin J. Fritzler +7 more
TL;DR: Antifibrillarin, although an infrequent nucleolar autoantibody, is a marker for severe SSc, especially in blacks and males, and is strongly associated with a unique HLA haplotype, as well as with combinations of certain HLA-DQB1 alleles.
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Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred, congenic, and intra-H-2 recombinant strains.
TL;DR: Inbred, congenic, and intra-H-2-recombinant mouse strains were given subcutaneous injections of either 1.6 mg HgCl2/kg body wt or 0.1 ml NaCl thrice weekly for 5-6 weeks to confirm earlier reports that expression of H-2E genes dampens the development of ANoA.