Ennio Esposito

TL;DR: The biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed and particular emphasis will be given to the role played by the nuclear transcription factor-kappaB (NF- kappaB) in apoptosis, and in the pathogenesis of neurodegenersative disorders, such as AD, PD, and ALS.

TL;DR: The biochemical mechanisms by which nutritional antioxidants can reduce or block neuronal death occurring in neurodegenerative disorders are reviewed and particular emphasis will be given to the role played by the nuclear transcription factor -kB (NF-kB) in apoptosis, and in the pathogenesis of neurodegenersative disorders, such as AD, PD, and ALS.

TL;DR: Data indicate that the central 5- HT system exerts a tonic and phasic inhibitory control on mesolimbic DA neuron activity and that 5-HT2C receptor subtypes are involved in this effect.

TL;DR: The role of 5-HT(2C) receptors in the control of brain DA function will be reviewed, and the search for new therapies for neuropsychiatric disorders, such as depression, schizophrenia and drug addiction, based on these findings will be discussed.

TL;DR: The results show that 5-HT2A and 5- HT2C receptors regulate specifically the activation of midbrain DA neurons induced by amphetamine and morphine, respectively, and suggest that 4-HT1C receptors selectively modulate the impulse flow–dependent release of DA.