Enrique Domínguez-Álvarez

TL;DR: The around 80 selenides and diselenides selected herein as representative compounds include promising antioxidant, prooxidant, redox-modulating, chemopreventive, anticancer, cytotoxic and radioprotective compounds, among other activities.

TL;DR: The present results revealed that analogues 5, 21, 28 and 30 might serve as a useful starting point for the design of improved anti-tumour agents.

TL;DR: The evaluated derivatives exerted a potent and selective cytotoxic activity and were strong apoptosis inducers as the four derivatives triggered apoptotic events in a 64-72% of the examined MDR Colo 320 human adenocarcinoma cells.

TL;DR: The potency of the selenocompounds as efflux pump inhibitors or the potentiation of their efficacy as reactive oxygen species modulators may play a role in their complementary activity against the tested MDR lymphoma cell line.

TL;DR: In this article, the authors investigated the performance of high sulfur-content heavy oil at sub-critical, near-critical and supercritical water (SCW) conditions, and showed that a viscosity reduction from 2073 to 1758mPa was achieved with a slight removal of sulfur (mainly sulfur) and the generation of a small amount of light and non-condensable hydrocarbons in gas phase (C1−C4, isoalkanes and alkenes, H2S, CO2 and H2, etc.).