Éric Aubin

TL;DR: Plant-based QVLP offers an attractive alternative manufacturing method for producing effective and HA-strain matching seasonal influenza vaccines and induced a substantial and sustained increase of hemagglutinin-specific polyfunctional CD4 T cells.

TL;DR: The ability of the low dose GLA-SE-adjuvanted H5VLP to elicit both humoral response and a sustained cross-reactive CMI in healthy adults is very attractive and could result in significant dose-sparing in a pandemic situation.

TL;DR: The inhibition of B cell-mediated antigen presentation reported here may help explain some of the anti-inflammatory effects of IVIg observed in treated patients, such as a decrease in autoantibody production.

TL;DR: The observations first suggest that spontaneous internalization can occur in IVIG-treated patients and also that some of the observed alterations in the physiology of IVIg-treated cells may not be only dependent on extracellular interactions ofIVIg with cell surface receptors or soluble plasma proteins but may also involve intracellular interactions.

TL;DR: The results indicate that most of the IgG present in IVIg are not involved in the formation of the soluble auto-IC, raising the possibility of preparing from IVIG a novel product which could be used for the treatment of the autoimmune diseases in which IC are thought to play an important role.