B
Bader Yassine-Diab
Researcher at Université de Montréal
Publications - 34
Citations - 4738
Bader Yassine-Diab is an academic researcher from Université de Montréal. The author has contributed to research in topics: T cell & CD8. The author has an hindex of 24, co-authored 34 publications receiving 4293 citations. Previous affiliations of Bader Yassine-Diab include French Institute of Health and Medical Research.
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Journal ArticleDOI
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Nicolas Chomont,Mohamed El-Far,Petronela Ancuta,Lydie Trautmann,Francesco A. Procopio,Bader Yassine-Diab,Geneviève Boucher,Mohamed Rachid Boulassel,Georges Ghattas,Jason M. Brenchley,Timothy W. Schacker,Brenna J. Hill,Daniel C. Douek,Jean-Pierre Routy,Elias K. Haddad,Elias K. Haddad,Rafick Pierre Sekaly +16 more
TL;DR: The results suggest that viral eradication might be achieved through the combined use of strategic interventions targeting viral replication and drugs that interfere with the self renewal and persistence of proliferating memory T cells.
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Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses
Denis Gaucher,René Therrien,Nadia Kettaf,Bastian R. Angermann,Geneviève Boucher,Abdelali Filali-Mouhim,Janice M. Moser,Riyaz Mehta,Donald Drake,Erika Castro,Rama Akondy,Aline Rinfret,Bader Yassine-Diab,Elias A. Said,Younes Chouikh,Mark J. Cameron,Robert Clum,David J. Kelvin,Roland Somogyi,Larry D. Greller,Robert S. Balderas,Peter Wilkinson,Giuseppe Pantaleo,Jim Tartaglia,Elias K. Haddad,Rafick Pierre Sekaly +25 more
TL;DR: The results clearly show that the immune response to a strong vaccine is preceded by coordinated induction of master transcription factors that lead to the development of a broad, polyfunctional, and persistent immune response that integrates all effector cells of the immune system.
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HIV-1 Viremia Prevents the Establishment of Interleukin 2–producing HIV-specific Memory CD4+ T Cells Endowed with Proliferative Capacity
Souheil Antoine Younes,Bader Yassine-Diab,Alam R. Dumont,Alam R. Dumont,Mohamed Rachid Boulassel,Zvi Grossman,Jean-Pierre Routy,Rafick Pierre Sekaly,Rafick Pierre Sekaly,Rafick Pierre Sekaly +9 more
TL;DR: The data favor a model whereby competent HIV-specific Tcm continuously arise in small numbers but under persistent antigenemia are rapidly induced to differentiate into IFN-γ only–producing cells that lack self-renewal capacity.
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Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses during Primary Infection Are Major Determinants of the Viral Set Point and Loss of CD4+ T Cells
Hendrik Streeck,Jonathan S. Jolin,Ying Qi,Bader Yassine-Diab,Randall C. Johnson,Douglas S. Kwon,Marylyn M. Addo,Chanson J. Brumme,Jean-Pierre Routy,Susan J. Little,Heiko Jessen,Anthony D. Kelleher,Frederick Hecht,Rafick-Pierre Sekaly,Eric S. Rosenberg,Bruce D. Walker,Bruce D. Walker,Mary Carrington,Marcus Altfeld +18 more
TL;DR: Data show that the specificity of the initial CTL response to HIV is critical for the subsequent control of viremia and have important implications for the rational selection of antigens for future HIV-1 vaccines.
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Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4 + central memory T cells
Catherine Riou,Bader Yassine-Diab,Julien van Grevenynghe,Julien van Grevenynghe,Roland Somogyi,Larry D. Greller,Dominic Gagnon,Sylvain Gimmig,Peter Wilkinson,Yu Shi,Mark J. Cameron,Roberto Campos-Gonzalez,Robert S. Balderas,David J. Kelvin,Rafick-Pierre Sekaly,Elias K. Haddad +15 more
TL;DR: It is demonstrated that ex vivo isolated TCM are more resistant to both spontaneous and Fas-induced apoptosis than TEM and have an increased capacity to proliferate and persist in vitro.