E
Eric F. Johnson
Researcher at Abbott Laboratories
Publications - 3
Citations - 725
Eric F. Johnson is an academic researcher from Abbott Laboratories. The author has contributed to research in topics: Veliparib & Temozolomide. The author has an hindex of 2, co-authored 3 publications receiving 672 citations.
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Journal ArticleDOI
ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models
Cherrie K. Donawho,Yan Luo,Yanping Luo,Thomas D. Penning,Joy Bauch,Jennifer J. Bouska,Velitchka Bontcheva-Diaz,Bryan F. Cox,Theodore L. DeWeese,Larry E. Dillehay,Debra Ferguson,Nayereh S. Ghoreishi-Haack,David R. Grimm,Ran Guan,Edward K. Han,Rhonda R. Holley-Shanks,Boris Hristov,Kenneth B. Idler,Ken Jarvis,Eric F. Johnson,Lawrence Kleinberg,Vered Klinghofer,Loren M. Lasko,Xuesong Liu,Kennan C. Marsh,Thomas McGonigal,Jonathan A. Meulbroek,Amanda M. Olson,Joann P. Palma,Luis E. Rodriguez,Yan Shi,Jason Stavropoulos,Alan C. Tsurutani,Gui Dong Zhu,Saul H. Rosenberg,Vincent L. Giranda,David Frost +36 more
TL;DR: ABT-888 is a potent inhibitor of PARP, has good oral bioavailability, can cross the blood-brain barrier, and potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models.
Journal ArticleDOI
Rationale for the combination of veliparib with platinum-based chemotherapy.
David Maag,Larry R. Solomon,Todd Hopkins,Gail Bukhofzer,Yan Shi,Cherrie K. Donawho,Gui-Dong Zhu,Luis E. Rodriguez,Thomas D. Penning,Enrico L. Digiammarino,Sanjay C. Panchal,Eric F. Johnson +11 more
TL;DR: This data indicates that treatment of tumors with impaired homologous status with PARP inhibitors results in down-regulation in the number of tumorigenicity and “cell reprograming events” is associated with disease progression.
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt. Bioorg Med Chem
Gui-Dong Zhu,Jianchun Gong,Viraj B. Gandhi,Keith W. Woods,Yan Luo,Xuesong Liu,Ran Guan,Vered Klinghofer,Eric F. Johnson,Vincent S. Stoll,Mulugeta Mamo,Qun Li,Saul H. Rosenberg,Vincent L. Giranda +13 more