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David R. Grimm
Researcher at Abbott Laboratories
Publications - 2
Citations - 792
David R. Grimm is an academic researcher from Abbott Laboratories. The author has contributed to research in topics: Temozolomide & Glioma. The author has an hindex of 2, co-authored 2 publications receiving 736 citations.
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Journal ArticleDOI
ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models
Cherrie K. Donawho,Yan Luo,Yanping Luo,Thomas D. Penning,Joy Bauch,Jennifer J. Bouska,Velitchka Bontcheva-Diaz,Bryan F. Cox,Theodore L. DeWeese,Larry E. Dillehay,Debra Ferguson,Nayereh S. Ghoreishi-Haack,David R. Grimm,Ran Guan,Edward K. Han,Rhonda R. Holley-Shanks,Boris Hristov,Kenneth B. Idler,Ken Jarvis,Eric F. Johnson,Lawrence Kleinberg,Vered Klinghofer,Loren M. Lasko,Xuesong Liu,Kennan C. Marsh,Thomas McGonigal,Jonathan A. Meulbroek,Amanda M. Olson,Joann P. Palma,Luis E. Rodriguez,Yan Shi,Jason Stavropoulos,Alan C. Tsurutani,Gui Dong Zhu,Saul H. Rosenberg,Vincent L. Giranda,David Frost +36 more
TL;DR: ABT-888 is a potent inhibitor of PARP, has good oral bioavailability, can cross the blood-brain barrier, and potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models.
Journal ArticleDOI
Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies.
Karen W.L. Yee,Anne E. Hagey,Srdan Verstovsek,Jorge E. Cortes,Guillermo Garcia-Manero,Susan O'Brien,Stefan Faderl,Deborah A. Thomas,William G. Wierda,Steven M. Kornblau,Alessandra Ferrajoli,Maher Albitar,Evelyn McKeegan,David R. Grimm,Toby Mueller,Rhonda R. Holley-Shanks,Leonardo Sahelijo,Gary Gordon,Hagop M. Kantarjian,Francis J. Giles +19 more
TL;DR: The maximum tolerated dose and toxicities of ABT-751 in patients with advanced myelodysplastic syndrome and relapsed or refractory acute leukemias were determined and a previously undescribed nonsynonymous single nucleotide polymorphism was identified in exon 4 of the β-tubulin gene, TUBB, in three other patients.