L
Lawrence Kleinberg
Researcher at Johns Hopkins University School of Medicine
Publications - 218
Citations - 9628
Lawrence Kleinberg is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Radiation therapy & Radiosurgery. The author has an hindex of 45, co-authored 182 publications receiving 7449 citations. Previous affiliations of Lawrence Kleinberg include University of Michigan & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models
Cherrie K. Donawho,Yan Luo,Yanping Luo,Thomas D. Penning,Joy Bauch,Jennifer J. Bouska,Velitchka Bontcheva-Diaz,Bryan F. Cox,Theodore L. DeWeese,Larry E. Dillehay,Debra Ferguson,Nayereh S. Ghoreishi-Haack,David R. Grimm,Ran Guan,Edward K. Han,Rhonda R. Holley-Shanks,Boris Hristov,Kenneth B. Idler,Ken Jarvis,Eric F. Johnson,Lawrence Kleinberg,Vered Klinghofer,Loren M. Lasko,Xuesong Liu,Kennan C. Marsh,Thomas McGonigal,Jonathan A. Meulbroek,Amanda M. Olson,Joann P. Palma,Luis E. Rodriguez,Yan Shi,Jason Stavropoulos,Alan C. Tsurutani,Gui Dong Zhu,Saul H. Rosenberg,Vincent L. Giranda,David Frost +36 more
TL;DR: ABT-888 is a potent inhibitor of PARP, has good oral bioavailability, can cross the blood-brain barrier, and potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models.
Journal ArticleDOI
Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.
Jaffer A. Ajani,Thomas A. D'Amico,David J. Bentrem,Joseph Chao,Carlos U. Corvera,Prajnan Das,Crystal S. Denlinger,Peter C. Enzinger,Paul T. Fanta,Farhood Farjah,Hans Gerdes,Michael Gibson,Robert E. Glasgow,James A. Hayman,Steven N. Hochwald,Wayne L. Hofstetter,David H. Ilson,Dawn E. Jaroszewski,Kimberly L. Johung,Rajesh N. Keswani,Lawrence Kleinberg,Stephen Leong,Quan P. Ly,Kristina A. Matkowskyj,Michael McNamara,Mary F. Mulcahy,Ravi Kumar Paluri,Haeseong Park,Kyle A. Perry,Jose M. Pimiento,George A. Poultsides,Robert E. Roses,Vivian E. Strong,Georgia L. Wiesner,Christopher G. Willett,Cameron D. Wright,Nicole R. McMillian,Lenora A. Pluchino +37 more
TL;DR: This selection from the NCCN Guidelines for Esophageal and Esophagogastric Junction Cancers focuses on recommendations for the management of locally advanced and metastatic adenocarcinoma of the esophagus and EGJ.
Journal ArticleDOI
Gastric Cancer, Version 3.2016; Clinical Practice Guidelines in Oncology
Jaffer A. Ajani,Thomas A. D'Amico,Khaldoun Almhanna,David J. Bentrem,Joseph Chao,Prajnan Das,Crystal S. Denlinger,Paul T. Fanta,Farhood Farjah,Charles S. Fuchs,Hans Gerdes,Michael K. Gibson,Robert E. Glasgow,James A. Hayman,Steven N. Hochwald,Wayne L. Hofstetter,David H. Ilson,Dawn E. Jaroszewski,Kimberly L. Johung,Rajesh N. Keswani,Lawrence Kleinberg,W. Michael Korn,Stephen Leong,Catherine Linn,A. Craig Lockhart,Quan P. Ly,Mary F. Mulcahy,Mark B. Orringer,Kyle A. Perry,George A. Poultsides,Walter J. Scott,Vivian E. Strong,Mary Kay Washington,Benny Weksler,Christopher G. Willett,Cameron D. Wright,Debra Zelman,Nicole R. McMillian,Hema Sundar +38 more
TL;DR: The recommendations outlined in the NCCN Guidelines for staging, assessment of HER2 overexpression, systemic therapy for locally advanced or metastatic disease, and best supportive care for the prevention and management of symptoms due to advanced disease are discussed.
Journal ArticleDOI
Gastric Cancer, Version 2.2013
Jaffer A. Ajani,David J. Bentrem,Stephen Besh,Thomas A. D'Amico,Prajnan Das,Crystal S. Denlinger,Marwan Fakih,Charles S. Fuchs,Hans Gerdes,Robert E. Glasgow,James A. Hayman,James A. Hayman,Wayne L. Hofstetter,David H. Ilson,Rajesh N. Keswani,Lawrence Kleinberg,Lawrence Kleinberg,W. Michael Korn,A. Craig Lockhart,Kenneth L. Meredith,Mary F. Mulcahy,Mark B. Orringer,Mark B. Orringer,James Posey,Aaron R. Sasson,Walter J. Scott,Vivian E. Strong,Thomas K. Varghese,Graham W. Warren,Mary Kay Washington,Christopher G. Willett,Cameron D. Wright,Nicole R. McMillian,Hema Sundar +33 more
TL;DR: The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer.
Journal ArticleDOI
Esophageal and esophagogastric junction cancers, version 1.2015.
Jaffer A. Ajani,Thomas A. D'Amico,Khaldoun Almhanna,David J. Bentrem,Stephen Besh,Joseph Chao,Prajnan Das,Crystal S. Denlinger,Paul T. Fanta,Charles S. Fuchs,Hans Gerdes,Robert E. Glasgow,James A. Hayman,Steven N. Hochwald,Wayne L. Hofstetter,David H. Ilson,Dawn E. Jaroszewski,Kory Jasperson,Rajesh N. Keswani,Lawrence Kleinberg,W. Michael Korn,Stephen Leong,A. Craig Lockhart,Mary F. Mulcahy,Mark B. Orringer,James Posey,George A. Poultsides,Aaron R. Sasson,Walter J. Scott,Vivian E. Strong,Thomas K. Varghese,Mary Kay Washington,Christopher G. Willett,Cameron D. Wright,Debra Zelman,Nicole R. McMillian,Hema Sundar +36 more
TL;DR: This portion of the NCCN Guidelines for Esophageal and EGJ Cancers discusses management of locally advanced adenocarcinoma of the esophagus andEGJ.