Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Machine learning

Data Mining - Concepts and Techniques.

Data Mining Practical Machine Learning Tools and Techniques

BIOE 402. Medical Technology Assessment. 2 or 3 hours. Bioentrepreneur course. Assessment of medical technology in the context of commercialization. Objectives, competition, market share, funding, pricing, manufacturing, growth, and intellectual property; many issues unique to biomedical products. Course Information: 2 undergraduate hours. 3 graduate hours. Prerequisite(s): Junior standing or above and consent of the instructor.

“Bioinformatics” 특집을 내면서

In recent years, many shape representations and geometric algorithms have been proposed for matching 3D shapes. Usually, each algorithm is tested on a different (small) database of 3D models, and thus no direct comparison is available for competing methods. We describe the Princeton Shape Benchmark (PSB), a publicly available database of polygonal models collected from the World Wide Web and a suite of tools for comparing shape matching and classification algorithms. One feature of the benchmark is that it provides multiple semantic labels for each 3D model. For instance, it includes one classification of the 3D models based on function, another that considers function and form, and others based on how the object was constructed (e.g., man-made versus natural objects). We find that experiments with these classifications can expose different properties of shape-based retrieval algorithms. For example, out of 12 shape descriptors tested, extended Gaussian images by B. Horn (1984) performed best for distinguishing man-made from natural objects, while they performed among the worst for distinguishing specific object types. Based on experiments with several different shape descriptors, we conclude that no single descriptor is best for all classifications, and thus the main contribution of this paper is to provide a framework to determine the conditions under which each descriptor performs best.

/pdf/the-princeton-shape-benchmark-2gmwi9i096.pdf

The Princeton Shape Benchmark

The description of the spatial characteristics of two- and three-dimensional objects, in the framework of MPEG-7, is considered. The shape of an object is one of its fundamental properties, and this paper describes an efficient way to represent the coarse shape, scale and composition properties of an object. This representation is invariant to resolution, translation and rotation, and may be used for both two-dimensional (2-D) and three-dimensional (3-D) objects. This coarse shape descriptor will be included in the eXperimentation Model (XM) of MPEG-7. Applications of such a description to search object databases, in particular the CAESAR anthropometric database are discussed.

Description of shape information for 2-D and 3-D objects

The CAESAR study (Civilian American and European Surface Anthropometry Resource) is a survey of body measurements for people ages 18-65 in three countries: USA, The Netherlands, and Italy. It is a collaborative effort with partners from several countries and many industries. It employs the latest in 3D measurement technology, and is the first 3D surface anthropometry survey of the US and Europe. Data from the study will allow us to effectively design everything from better fitting clothes and protective equipment to better seats and workstations, as well as dramatically reducing the cost to design and manufacture them.

The CAESAR project: a 3-D surface anthropometry survey

Macromolecular structures, such as neuraminidases, hemagglutinins, and monoclonal antibodies, are not rigid entities. Rather, they are characterised by their flexibility, which is the result of the interaction and collective motion of their constituent atoms. This conformational diversity has a significant impact on their physicochemical and biological properties. Among these are their structural stability, the transport of ions through the M2 channel, drug resistance, macromolecular docking, binding energy, and rational epitope design. To assess these properties and to calculate the associated thermodynamical observables, the conformational space must be efficiently sampled and the dynamic of the constituent atoms must be simulated. This paper presents algorithms and techniques that address the abovementioned issues. To this end, a computational review of molecular dynamics, Monte Carlo simulations, Langevin dynamics, and free energy calculation is presented. The exposition is made from first principles to promote a better understanding of the potentialities, limitations, applications, and interrelations of these computational methods.

https://downloads.hindawi.com/journals/bmri/2015/183918.pdf

Molecular Dynamics, Monte Carlo Simulations, and Langevin Dynamics: A Computational Review

Nefertiti: a query by content system for three-dimensional model and image databases management

This paper presents a new approach for the classification and retrieval of three-dimensional images and models from databases. A set of retrieval algorithms is introduced. These algorithms are content-based, meaning that the input is not made out of keywords but of three-dimensional models. Tensor of inertia, distribution of normals, distribution of cords and multiresolution analysis are used to describe each model. The database can be searched by scale, shape or color or any combination of these parameters. A user friendly interface makes the retrieval operation simple and intuitive and allows to edit reference models according to the specifications of the user. Experimental results using a database of more than 400 range images and 1000 VRML models are presented.

Eric Paquet

Papers

Description of shape information for 2-D and 3-D objects

The CAESAR project: a 3-D surface anthropometry survey

Molecular Dynamics, Monte Carlo Simulations, and Langevin Dynamics: A Computational Review

Nefertiti: a query by content system for three-dimensional model and image databases management

Nefertiti: a query by content software for three-dimensional models databases management