E
Eric S. Sobel
Researcher at University of Florida
Publications - 120
Citations - 5030
Eric S. Sobel is an academic researcher from University of Florida. The author has contributed to research in topics: Systemic lupus erythematosus & Autoantibody. The author has an hindex of 43, co-authored 119 publications receiving 4581 citations. Previous affiliations of Eric S. Sobel include University of Texas Southwestern Medical Center & University of Occupational and Environmental Health Japan.
Papers
More filters
Journal ArticleDOI
Normalization of CD4+ T cell metabolism reverses lupus
Yiming Yin,Seung Chul Choi,Zhiwei Xu,Daniel J. Perry,Howard R. Seay,Byron P. Croker,Eric S. Sobel,Todd M. Brusko,Laurence Morel +8 more
TL;DR: It is shown that both glycolysis and mitochondrial oxidative metabolism are elevated in CD4+ T cells from lupus-prone B6.Sle3 (TC) mice as compared to non-autoimmune controls, and inhibition of these pathways currently in the clinic normalized T cell metabolism and reversed disease biomarkers.
Journal ArticleDOI
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Pui Y. Lee,Yi Li,Hanno B. Richards,Fay S. Chan,Haoyang Zhuang,Sonali Narain,Edward J. Butfiloski,Eric S. Sobel,Westley H. Reeves,Mark S. Segal +9 more
TL;DR: The novel hypothesis that depletion of EPCs caused by excessive IFN-I may be linked to endothelial dysfunction and increased cardiovascular risk in SLE is supported.
Journal ArticleDOI
An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.
TL;DR: It is shown that expression of the lPR gene in B cells is absolutely necessary for autoantibody production in the lpr model and that normal B cells showed little response to an exogenous, T cell-dependent antigen in the presence of lpr B cells.
Journal ArticleDOI
Deficiency of the type I interferon receptor protects mice from experimental lupus.
Dina C. Nacionales,Kindra M. Kelly-Scumpia,Pui Y. Lee,Jason S. Weinstein,Robert Lyons,Eric S. Sobel,Minoru Satoh,Westley H. Reeves +7 more
TL;DR: The clinical and serologic manifestations observed in TMPD-treated mice were strongly dependent on IFNAR signaling, which is consistent with the association of increased expression of ISGs with lupus-specific autoantibodies and nephritis in humans.
Journal ArticleDOI
Type I Interferon Modulates Monocyte Recruitment and Maturation in Chronic Inflammation
Pui Y. Lee,Yi Li,Yutaro Kumagai,Yuan Xu,Jason S. Weinstein,Erinn S. Kellner,Dina C. Nacionales,Edward J. Butfiloski,Nico van Rooijen,Shizuo Akira,Eric S. Sobel,Minoru Satoh,Westley H. Reeves +12 more
TL;DR: In this article, the authors reveal a novel role of IFN-I in promoting the recruitment of inflammatory monocytes via the chemokine receptor CCR2, which may help sustain the chronic inflammatory response.