S
Suzanne C. Morris
Researcher at University of Cincinnati Academic Health Center
Publications - 66
Citations - 6990
Suzanne C. Morris is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: T cell & Interleukin 4. The author has an hindex of 39, co-authored 64 publications receiving 6689 citations. Previous affiliations of Suzanne C. Morris include Veterans Health Administration & Cincinnati Children's Hospital Medical Center.
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Journal ArticleDOI
CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES: Lessons from Studies with Rodent Models
Fred D. Finkelman,Terez Shea-Donohue,J. M. Goldhill,Carolyn Sullivan,Suzanne C. Morris,Suzanne C. Morris,Kathleen B. Madden,William C. Gause,Joseph F. Urban +8 more
TL;DR: Studies with rodents infected with Trichinella spiralis, Heligmosomoides polygyrus, Nippostronglyus brasiliensis, and Trichuris muris have provided considerable information about immune mechanisms that protect against parasitic gastrointestinal nematodes.
Journal ArticleDOI
IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis
Joseph F. Urban,Nancy Noben-Trauth,Debra D. Donaldson,Kathleen B. Madden,Suzanne C. Morris,Suzanne C. Morris,Mary Collins,Fred D. Finkelman,Fred D. Finkelman +8 more
TL;DR: It is demonstrated that Stat6 signaling is not required for IL-4 enhancement of IgG1 production and actually inhibits IL- 4-induction of mucosal mastocytosis, and IL-13 may be more important thanIL-4 as an inducer of the Stat6 signaled signaling that leads to worm expulsion.
Journal ArticleDOI
Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites.
Fred D. Finkelman,Fred D. Finkelman,Terez Shea-Donohue,Suzanne C. Morris,Lucy A. Gildea,Richard T. Strait,Kathleen B. Madden,Lisa Schopf,Joseph F. Urban +8 more
TL;DR: It is argued that a limited ability of the host immune system to distinguish among different nematode parasites has led to the evolution of a stereotyped Th2 response that activates a set of effector mechanisms that protects against most intestinal nematodes parasites.
Journal Article
Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes.
Fred D. Finkelman,Kathleen B. Madden,Suzanne C. Morris,J M Holmes,N Boiani,Ildy M. Katona,C R Maliszewski +6 more
TL;DR: Injection of mice with mixtures of IL-4 and either of two neutralizing anti-IL-4 mAb, at a cytokine/anti-cytokine mAb molar ratio of approximately 2:1, enhances and prolongs in vivo IL- 4 activity, as measured by induction of increased spleen cell Ia expression.
Journal Article
Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.
TL;DR: Observations indicate that DCs can present Ag in either a tolerogenic or stimulatory manner and suggest that inflammatory stimuli can convert an otherwise tolerogenic signal to a stimulatory signal.