Eric Tschirhart

TL;DR: Major constraints associated with a trip to Mars are summarized, immunological hazards associated with this type of mission are presented, and it is shown that current understanding of the immunosuppressive effects of spaceflight is limited.

TL;DR: Sialic acid residues might be involved in the initial binding of peptides and compound 48/80 to mast cells, which activate a pertussis toxin-sensitive G-protein and allows the increase in phospholipase C activity to induce exocytosis, which might characterize the physiological pathway of mast cell activation by peptides, without necessarily requiring selective membrane receptors.

TL;DR: The role of calcium influx in the control of the NADPH oxidase is emphasized and the current knowledge of pathways mediating this extracellular calcium entry in neutrophils is summarized.

TL;DR: It seems unlikely that N-palmitoylethanolamide is an endogenous agonist of the CB(2) receptors but it may be a compound with potential therapeutic applications since it may act via other mechanisms than cannabinoid CB(1)-CB( 2) receptor interactions.

TL;DR: It is shown that store-operated Ca(2+) entry (SOCE) is required at the beginning of NADPH oxidase activation in response to fMLF in neutrophil-like HL-60 cells.