C
Christine Legrand-Frossi
Researcher at University of Lorraine
Publications - 9
Citations - 474
Christine Legrand-Frossi is an academic researcher from University of Lorraine. The author has contributed to research in topics: Spaceflight & Lymphocyte. The author has an hindex of 6, co-authored 9 publications receiving 410 citations. Previous affiliations of Christine Legrand-Frossi include Henri Poincaré University.
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Journal ArticleDOI
Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit?
Nathan Guéguinou,Cécile Huin-Schohn,Matthieu Bascove,Jean-Luc Bueb,Eric Tschirhart,Christine Legrand-Frossi,Jean-Pol Frippiat +6 more
TL;DR: Major constraints associated with a trip to Mars are summarized, immunological hazards associated with this type of mission are presented, and it is shown that current understanding of the immunosuppressive effects of spaceflight is limited.
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Stress response and humoral immune system alterations related to chronic hypergravity in mice.
Nathan Guéguinou,Mickael Bojados,Marc Jamon,Hanane Derradji,Sarah Baatout,Eric Tschirhart,Jean-Pol Frippiat,Christine Legrand-Frossi +7 more
TL;DR: Functional immune dysregulations and stress responses were dependent of the gravity level and no difference was observed in the 3G group with these isotypes.
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Three weeks of murine hindlimb unloading induces shifts from B to T and from th to tc splenic lymphocytes in absence of stress and differentially reduces cell-specific mitogenic responses.
Fanny Gaignier,Véronique Schenten,Marcelo De Carvalho Bittencourt,Guillemette Gauquelin-Koch,Jean-Pol Frippiat,Christine Legrand-Frossi +5 more
TL;DR: It is shown for the first time that, even if restraint has its own effects on the animals and their splenic lymphocytes, the prolonged antiorthostatic position leads, despite the absence of stress, to an inversion of the B/T ratio in the spleen.
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Comparison of seven methods for extraction of bacterial DNA from fecal and cecal samples of mice.
Janina Ferrand,Kévin Patron,Christine Legrand-Frossi,Jean-Pol Frippiat,Christophe Merlin,Corentine Alauzet,Alain Lozniewski +6 more
TL;DR: For both feces and intestinal contents, the most efficient extraction method was the FastDNA® SPIN Kit for Soil.
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Comparison between intestinal and non-mucosal immune functions of rainbow trout, Oncorhynchus mykiss.
TL;DR: Comparison of intestinal leukocyte suspensions with their head kidney or peripheral blood counterparts to highlight characteristics of intestinal immune functions in healthy rainbow trout shows that intestinal phagocytes are less activated by yeast cells but when they are activated they can ingest as many yeast cells as their HK counterparts.