There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

The discovery that mammalian cells generate nitric oxide, a gas previously considered to be merely an atmospheric pollutant, is providing important information about many biologic processes. Nitric oxide is synthesized from the amino acid L-arginine by a family of enzymes, the nitric oxide synthases, through a hitherto unrecognized metabolic route -- namely, the L-arginine-nitric oxide pathway1–8. The synthesis of nitric oxide by vascular endothelium is responsible for the vasodilator tone that is essential for the regulation of blood pressure. In the central nervous system nitric oxide is a neurotransmitter that underpins several functions, including the formation of memory. . . .

The L-Arginine-Nitric Oxide Pathway

/pdf/convex-analysisnoer-san-nojin-zhan-nituite-5dl2rbmoyr.pdf

Convex Analysisの二,三の進展について

Our growing dependence on increasingly complex computer and software systems necessitates the development of formalisms, techniques, and tools for assessing functional properties of these systems. One such technique that has emerged in the last twenty years is model checking, which systematically (and automatically) checks whether a model of a given system satisfies a desired property such as deadlock freedom, invariants, and request-response properties. This automated technique for verification and debugging has developed into a mature and widely used approach with many applications. Principles of Model Checking offers a comprehensive introduction to model checking that is not only a text suitable for classroom use but also a valuable reference for researchers and practitioners in the field. The book begins with the basic principles for modeling concurrent and communicating systems, introduces different classes of properties (including safety and liveness), presents the notion of fairness, and provides automata-based algorithms for these properties. It introduces the temporal logics LTL and CTL, compares them, and covers algorithms for verifying these logics, discussing real-time systems as well as systems subject to random phenomena. Separate chapters treat such efficiency-improving techniques as abstraction and symbolic manipulation. The book includes an extensive set of examples (most of which run through several chapters) and a complete set of basic results accompanied by detailed proofs. Each chapter concludes with a summary, bibliographic notes, and an extensive list of exercises of both practical and theoretical nature.

/pdf/principles-of-model-checking-249iimickz.pdf

Principles of Model Checking

ATS/ACCP statement on cardiopulmonary exercise testing.

1. Introduction: The Classical Decision Problem.- 1.1 The Original Problem.- 1.2 The Transformation of the Classical Decision Problem.- 1.3 What Is and What Isn't in this Book.- I. Undecidable Classes.- 2. Reductions.- 2.1 Undecidability and Conservative Reduction.- 2.1.1 The Church-Turing Theorem and Reduction Classes.- 2.1.2 Trakhtenbrot's Theorem and Conservative Reductions.- 2.1.3 Inseparability and Model Complexity.- 2.2 Logic and Complexity.- 2.2.1 Propositional Satisfiability.- 2.2.2 The Spectrum Problem and Fagin's Theorem.- 2.2.3 Capturing Complexity Classes.- 2.2.4 A Decidable Prefix-Vocabulary Class.- 2.3 The Classifiability Problem.- 2.3.1 The Problem.- 2.3.2 Well Partially Ordered Sets.- 2.3.3 The Well Quasi Ordering of Prefix Sets.- 2.3.4 The Well Quasi Ordering of Arity Sequences.- 2.3.5 The Classifiability of Prefix-Vocabulary Sets.- 2.4 Historical Remarks.- 3. Undecidable Standard Classes for Pure Predicate Logic.- 3.1 The Kahr Class.- 3.1.1 Domino Problems.- 3.1.2 Formalization of Domino Problems by $$[\forall \exists \forall , (0,\omega )]$$-Formulae.- 3.1.3 Graph Interpretation of $$[\forall \exists \forall , (0,\omega )]$$-Formulae.- 3.1.4 The Remaining Cases Without $$\exists *$$.- 3.2 Existential Interpretation for $$[{{\forall }^{3}}\exists *, (0,1)]$$.- 3.3 The Gurevich Class.- 3.3.1 The Proof Strategy.- 3.3.2 Reduction to Diagonal-Freeness.- 3.3.3 Reduction to Shift-Reduced Form.- 3.3.4 Reduction toFi-Elimination Form.- 3.3.5 Elimination of MonadicFi.- 3.3.6 The Kostyrko-Genenz and Suranyi Classes.- 3.4 Historical Remarks.- 4. Undecidable Standard Classes with Functions or Equality.- 4.1 Classes with Functions and Equality.- 4.2 Classes with Functions but Without Equality.- 4.3 Classes with Equality but Without Functions: the Goldfarb Classes 161 4.3.1 Formalization of Natural Numbers in $$[{{\forall }^{3}}\exists *, (\omega ,\omega ),(0)]$$=.- 4.3.2 Using Only One Existential Quantifiers.- 4.3.3 Encoding the Non-Auxiliary Binary Predicates.- 4.3.4 Encoding the Auxiliary Binary Predicates of NUM*.- 4.4 Historical Remarks.- 5. Other Undecidable Cases.- 5.1 Krom and Horn Formulae.- 5.1.1 Krom Prefix Classes Without Functions or Equality.- 5.1.2 Krom Prefix Classes with Functions or Equality.- 5.2 Few Atomic Subformulae.- 5.2.1 Few Function and Equality Free Atoms.- 5.2.2 Few Equalities and Inequalities.- 5.2.3 Horn Clause Programs With One Krom Rule.- 5.3 Undecidable Logics with Two Variables.- 5.3.1 First-Order Logic with the Choice Operator.- 5.3.2 Two-Variable Logic with Cardinality Comparison.- 5.4 Conjunctions of Prefix-Vocabulary Classes.- 5.4.1 Reduction to the Case of Conjunctions.- 5.4.2 Another Classifiability Theorem.- 5.4.3 Some Results and Open Problems.- 5.5 Historical Remarks.- II. Decidable Classes and Their Complexity.- 6. Standard Classes with the Finite Model Property.- 6.1 Techniques for Proving Complexity Results.- 6.1.1 Domino Problems Revisited.- 6.1.2 Succinct Descriptions of Inputs.- 6.2 The Classical Solvable Cases.- 6.2.1 Monadic Formulae.- 6.2.2 The Bernays-Schonfinkel-Ramsey Class.- 6.2.3 The Godel-Kalmar-Schutte Class: a Probabilistic Proof.- 6.3 Formulae with One ?.- 6.3.1 A Satisfiability Test for [?*??*, all, all].- 6.3.2 The Ackermann Class.- 6.3.3 The Ackermann Class with Equality.- 6.4 Standard Classes of Modest Complexity.- 6.4.1 The Relational Classes in P, NP and Co-NP.- 6.4.2 Fragments of the Theory of One Unary Function.- 6.4.3 Other Functional Classes.- 6.5 Finite Model Property vs. Infinity Axioms.- 6.6 Historical Remarks.- 7. Monadic Theories and Decidable Standard Classes with Infinity Axioms.- 7.1 Automata, Games and Decidability of Monadic Theories.- 7.1.1 Monadic Theories.- 7.1.2 Automata on Infinite Words and the Monadic Theory of One Successor.- 7.1.3 Tree Automata, Rabin's Theorem and Forgetful De terminacy.- 7.1.4 The Forgetful Determinacy Theorem for Graph Games.- 7.2 The Monadic Second-Order Theory of One Unary Function.- 7.2.1 Decidability Results for One Unary Function.- 7.2.2 The Theory of One Unary Function is not Elementary Recursive.- 7.3 The Shelah Class.- 7.3.1 Algebras with One Unary Operation.- 7.3.2 Canonic Sentences.- 7.3.3 Terminology and Notation.- 7.3.4 1-Satisfiability.- 7.3.5 2-Satisfiability.- 7.3.6 Refinements.- 7.3.7 Villages.- 7.3.8 Contraction.- 7.3.9 Towns.- 7.3.10 The Final Reduction.- 7.4 Historical Remarks.- 8. Other Decidable Cases.- 8.1 First-Order Logic with Two Variables.- 8.2 Unification and Applications to the Decision Problem.- 8.2.1 Unification.- 8.2.2 Herbrand Formulae.- 8.2.3 Positive First-Order Logic.- 8.3 Decidable Classes of Krom Formulae.- 8.3.1 The Chain Criterion.- 8.3.2 The Aanderaa-Lewis Class.- 8.3.3 The Maslov Class.- 8.4 Historical Remarks.- A. Appendix: Tiling Problems.- A.1 Introduction.- A.2 The Origin Constrained Domino Problem.- A.3 Robinson's Aperiodic Tile Set.- A.4 The Unconstrained Domino Problem.- A.5 The Periodic Problem and the Inseparability Result.- Annotated Bibliography.

The classical decision problem

A central aim and ever-lasting dream of computer science is to put the development of hardware and software systems on a mathematical basis which is both firm and practical. Such a scientific foundation is needed especially for the construction of reactive programs, like communication protocols or control systems.

For the construction and analysis of reactive systems an elegant and powerful theory has been developed based on automata theory, logical systems for the specification of nonterminating behavior, and infinite two-person games.

The 19 chapters presented in this multi-author monograph give a consolidated overview of the research results achieved in the theory of automata, logics, and infinite games during the past 10 years. Special emphasis is placed on coherent style, complete coverage of all relevant topics, motivation, examples, justification of constructions, and exercises.

Automata logics, and infinite games: a guide to current research

Both the internal mammary artery and the saphenous vein are used to construct coronary-artery bypass grafts. We hypothesized that the release or production of endothelium-derived relaxing factor, which regulates blood flow and inhibits platelet function, may differ in venous and arterial grafts. We therefore studied endothelium-dependent relaxation in internal mammary arteries, internal mammary veins, and saphenous veins obtained from 58 patients undergoing coronary bypass surgery. Vascular rings with and without endothelium were suspended in organ chambers, and isometric tension was recorded. Acetylcholine (10(-8) to 10(-4) M), thrombin (1 U per milliliter), and adenosine diphosphate (10(-7) to 10(-4) M) evoked potent endothelium-dependent relaxation in the mammary artery but weak response in the saphenous vein (P less than 0.005; n = 6 to 27). In the mammary artery, relaxation was greatest in response to acetylcholine (86 +/- 4 percent reduction in norepinephrine-induced tension), followed by thrombin (44 +/- 7 percent) and adenosine diphosphate (39 +/- 8 percent). In the saphenous and mammary veins, relaxation was less than 25 percent. Relaxation was unaffected by indomethacin but was inhibited by methylene blue and hemoglobin (P less than 0.005 and 0.01, respectively), which suggests that endothelium-derived relaxing factor was the mediator. Endothelium-independent relaxation in response to sodium nitroprusside was similar in arteries and veins. We conclude that endothelium-dependent relaxation is greater in the mammary artery than in the saphenous vein. The possibility that this contributes to the higher patency rate among arterial grafts than among venous grafts will require further study.

Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts.

Automata Logics, and Infinite Games

Guarded fragments of first-order logic were recently introduced by Andreka, van Benthem and Nemeti; they consist of relational first-order formulae whose quantifiers are appropriately relativized by atoms. These fragments are interesting because they extend in a natural way many propositional modal logics, because they have useful model-theoretic properties and especially because they are decidable classes that avoid the usual syntactic restrictions (on the arity of relation symbols, the quantifier pattern or the number of variables) of almost all other known decidable fragments of first-order logic.Here, we investigate the computational complexity of these fragments. We prove that the satisfiability problems for the guarded fragment (GF) and the loosely guarded fragment (LGF) of first-order logic are complete for deterministic double exponential time. For the subfragments that have only a bounded number of variables or only relation symbols of bounded arity, satisfiability is Exptime-complete. We further establish a tree model property for both the guarded fragment and the loosely guarded fragment, and give a proof of the finite model property of the guarded fragment.It is also shown that some natural, modest extensions of the guarded fragments are undecidable.

Erich Grädel

Papers

The classical decision problem

Automata logics, and infinite games: a guide to current research

Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts.

Automata Logics, and Infinite Games

On the Restraining Power of Guards