E
Erich Lieth
Researcher at Pennsylvania State University
Publications - 15
Citations - 3717
Erich Lieth is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Diabetic retinopathy & Glutamate receptor. The author has an hindex of 13, co-authored 15 publications receiving 3493 citations. Previous affiliations of Erich Lieth include Penn State Milton S. Hershey Medical Center & Geisinger Health System.
Papers
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Journal ArticleDOI
Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.
Alistair J. Barber,Erich Lieth,Sonny Khin,David A. Antonetti,Adam G. Buchanan,Thomas W. Gardner +5 more
TL;DR: This is the first quantitative report of an increase in neural cell apoptosis in the retina during diabetes, and indicates that neurodegeneration is an important component of diabetic retinopathy.
Journal ArticleDOI
Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.
David A. Antonetti,Alistair J. Barber,Sonny Khin,Erich Lieth,John M. Tarbell,Thomas W. Gardner +5 more
TL;DR: These data show that diabetes selectively reduces retinal occludin protein expression and increases BRB permeability, and suggest that the elevated VEGF in the vitreous of patients with diabetic retinopathy increases vascular permeability by downregulating occlUDin content.
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Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group.
Erich Lieth,Alistair J. Barber,Baiyang Xu,Chelsea Dice,Chelsea Dice,Michael J. Ratz,Diana Tanase,John M. Strother +7 more
TL;DR: It is indicated that glial reactivity and altered glial glutamate metabolism are early pathogenic events that may lead to elevated retinal glutamate during diabetes.
Journal ArticleDOI
Retinal neurodegeneration: early pathology in diabetes.
TL;DR: The collective evidence from past and recent studies supports the hypothesis that neurodegeneration, together with functional changes in the vasculature, is an important component of diabetic retinopathy.
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Molecular Mechanisms of Vascular Permeability in Diabetic Retinopathy
TL;DR: The molecular components that form this blood-retinal barrier are examined and how changes in the production of growth factors in the neural parenchyma cause an increase in vascular permeability and contribute to retinal degeneration are explored.