E
Erich Lieth
Researcher at Pennsylvania State University
Publications - 15
Citations - 3717
Erich Lieth is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Diabetic retinopathy & Glutamate receptor. The author has an hindex of 13, co-authored 15 publications receiving 3493 citations. Previous affiliations of Erich Lieth include Penn State Milton S. Hershey Medical Center & Geisinger Health System.
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Journal ArticleDOI
Nitrogen shuttling between neurons and glial cells during glutamate synthesis.
Erich Lieth,Kathryn F. LaNoue,Deborah A. Berkich,Baiyang Xu,Michael J. Ratz,Charles Taylor,Susan M. Hutson +6 more
TL;DR: The relationship between neuronal glutamate turnover, the glutamate/glutamine cycle and de novo glutamate synthesis was examined using two different model systems, freshly dissected rat retinas ex vivo and in vivo perfused rat brains to suggest that the cycle is closely linked to neuronal activity.
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Diabetes Reduces Glutamate Oxidation and Glutamine Synthesis in the Retina
TL;DR: The results indicate two enzymatic abnormalities in the glutamate metabolism pathway in the retina during diabetes: transamination to alpha-ketoglutarate and amination to glutamine and the reduced flux through these pathways may be associated with the accumulation of glutamate.
Journal Article
Astrocytes Increase Barrier Properties and ZO-1 Expression in Retinal Vascular Endothelial Cells
Thomas W. Gardner,Erich Lieth,Sonny Khin,Alistair J. Barber,Dean J. Bonsall,Treena Lesher,Keith Rice,William A. Brennan +7 more
TL;DR: The results suggest that astrocytes enhance blood-retinal barrier properties, at least in part by increasing tight junction protein expression, and suggest that glial malfunction plays an important role in the pathogenesis of vasogenic retinal edema.
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Function of Leucine in Excitatory Neurotransmitter Metabolism in the Central Nervous System
TL;DR: Evidence in favor of the hypothesis is: 1) the two BCAT isoenzymes appear to be localized separately in the neurons (BCATc) or in the astroglia ( BCATm). 2) Inhibition of the shuttle in the direction of glutamate synthesis can be achieved by inhibiting BCATc using the neuroactive drug gabapentin.
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Agrin accumulates in the brain microvascular basal lamina during development of the blood-brain barrier
Alistair J. Barber,Erich Lieth +1 more
TL;DR: Results indicate that agrins may function as important players in the formation and maintenance of cerebral microvascular impermeability in adult brains of both species.