There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

What will 5G be? What it will not be is an incremental advance on 4G. The previous four generations of cellular technology have each been a major paradigm shift that has broken backward compatibility. Indeed, 5G will need to be a paradigm shift that includes very high carrier frequencies with massive bandwidths, extreme base station and device densities, and unprecedented numbers of antennas. However, unlike the previous four generations, it will also be highly integrative: tying any new 5G air interface and spectrum together with LTE and WiFi to provide universal high-rate coverage and a seamless user experience. To support this, the core network will also have to reach unprecedented levels of flexibility and intelligence, spectrum regulation will need to be rethought and improved, and energy and cost efficiencies will become even more critical considerations. This paper discusses all of these topics, identifying key challenges for future research and preliminary 5G standardization activities, while providing a comprehensive overview of the current literature, and in particular of the papers appearing in this special issue.

What Will 5G Be

The global bandwidth shortage facing wireless carriers has motivated the exploration of the underutilized millimeter wave (mm-wave) frequency spectrum for future broadband cellular communication networks. There is, however, little knowledge about cellular mm-wave propagation in densely populated indoor and outdoor environments. Obtaining this information is vital for the design and operation of future fifth generation cellular networks that use the mm-wave spectrum. In this paper, we present the motivation for new mm-wave cellular systems, methodology, and hardware for measurements and offer a variety of measurement results that show 28 and 38 GHz frequencies can be used when employing steerable directional antennas at base stations and mobile devices.

Millimeter Wave Mobile Communications for 5G Cellular: It Will Work!

Multi-user MIMO offers big advantages over conventional point-to-point MIMO: it works with cheap single-antenna terminals, a rich scattering environment is not required, and resource allocation is simplified because every active terminal utilizes all of the time-frequency bins. However, multi-user MIMO, as originally envisioned, with roughly equal numbers of service antennas and terminals and frequency-division duplex operation, is not a scalable technology. Massive MIMO (also known as large-scale antenna systems, very large MIMO, hyper MIMO, full-dimension MIMO, and ARGOS) makes a clean break with current practice through the use of a large excess of service antennas over active terminals and time-division duplex operation. Extra antennas help by focusing energy into ever smaller regions of space to bring huge improvements in throughput and radiated energy efficiency. Other benefits of massive MIMO include extensive use of inexpensive low-power components, reduced latency, simplification of the MAC layer, and robustness against intentional jamming. The anticipated throughput depends on the propagation environment providing asymptotically orthogonal channels to the terminals, but so far experiments have not disclosed any limitations in this regard. While massive MIMO renders many traditional research problems irrelevant, it uncovers entirely new problems that urgently need attention: the challenge of making many low-cost low-precision components that work effectively together, acquisition and synchronization for newly joined terminals, the exploitation of extra degrees of freedom provided by the excess of service antennas, reducing internal power consumption to achieve total energy efficiency reductions, and finding new deployment scenarios. This article presents an overview of the massive MIMO concept and contemporary research on the topic.

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Massive MIMO for next generation wireless systems

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Linköping University Pre Print Computational Complexity of Decoding Orthogonal Space-Time Block Codes

FIELD: computer equipment.SUBSTANCE: invention relates to computer engineering. Method in a network node for encoding bits of control information of transmission of High-Speed Shared Control Channel (HS-SCCH) downlink signaling, comprising steps of: determining that channel conditions are below a threshold level; in response to determining that the channel conditions are below a threshold level, performing at least one of: encoding one or more HS-SCCH control information bits as the predetermined control information bits in the downlink control channel transmission and encoding the shorter number of bits of the HS-SCCH control information in the downlink control channel transmission by eliminating one or more HS-SCCH control information bits, wherein one or more excluded bits of HS-SCCH control information are predetermined control information bits; and transmitting encoded HS-SCCH control information bits to user equipment.EFFECT: technical result consists in improvement of network coverage without increasing power.32 cl, 13 dwg

Methods and device for encoding and decoding downlink control channel transmission

A fundamental algorithm for data analytics at the edge of wireless networks is distributed principal component analysis (DPCA), which finds the most important information embedded in a distributed high-dimensional dataset by distributed computation of a reduced-dimension data subspace, called principal components (PCs). In this paper, to support one-shot DPCA in wireless systems, we propose a framework of analog MIMO transmission featuring the uncoded analog transmission of local PCs for estimating the global PCs. To cope with channel distortion and noise, two maximum-likelihood (global) PC estimators are presented corresponding to the cases with and without receive channel state information (CSI). The first design, termed coherent PC estimator, is derived by solving a Procrustes problem and reveals the form of regularized channel inversion where the regulation attempts to alleviate the effects of both channel noise and data noise. The second one, termed blind PC estimator, is designed based on the subspace channel-rotation-invariance property and computes a centroid of received local PCs on a Grassmann manifold. Using the manifold-perturbation theory, tight bounds on the mean square subspace distance (MSSD) of both estimators are derived for performance evaluation. The results reveal simple scaling laws of MSSD concerning device population, data and channel signal-to-noise ratios (SNRs), and array sizes. More importantly, both estimators are found to have identical scaling laws, suggesting the dispensability of CSI to accelerate DPCA. Simulation results validate the derived results and demonstrate the promising latency performance of the proposed analog MIMO.

Analog MIMO Communication for One-shot Distributed Principal Component Analysis.

A factor present in the supernatant of an established human glioma cell line U-251 MG strongly suppresses feline sarcoma virus (FeSV) focus forming activity on feline embryo fibroblasts. The factor was identified as mycoplasma arginini. The enriched mycoplasma fraction had no cytpathogenic effect on the glioma cells or on the embryonic feline indicator cells. An antiserum prepared against this strain of mycoplasma abolished the inhibition. The exact mechanism is not known but arginine depletion in the medium seems to be an important factor.

Interaction of feline sarcoma virus (FeSV) and mycoplasma.

We consider the slow-fading two-user multiple-input single-output (MISO) interference channel. We want to understand which rate points can be achieved, allowing a non-zero outage probability. We do so by defining four different outage rate regions. The definitions differ on whether the rates are declared in outage jointly or individually and whether the transmitters have instantaneous or statistical channel state information (CSI). The focus is on the instantaneous CSI case with individual outage, where we propose a stochastic mapping from the rate point and the channel realization to the beamforming vectors. A major contribution is that we prove that the stochastic component of this mapping is independent of the actual channel realization.

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Erik G. Larsson

Papers

Linköping University Pre Print Computational Complexity of Decoding Orthogonal Space-Time Block Codes

Methods and device for encoding and decoding downlink control channel transmission

Analog MIMO Communication for One-shot Distributed Principal Component Analysis.

Interaction of feline sarcoma virus (FeSV) and mycoplasma.

Achievable Outage Rate Regions for the MISO Interference Channel