Erik J. Henriksen

TL;DR: It is clear that further investigations are needed to further elucidate the specific molecular mechanisms underlying the beneficial effects of acute exercise and exercise training on the glucose transport system in insulin-resistant mammalian skeletal muscle.

TL;DR: The importance of oxidative stress in the development of insulin resistance in mammalian skeletal muscle tissue is highlighted, at least in part via a p38-MAPK-dependent mechanism, and interventions that reduce this oxidative stress and oxidative damage can improve insulin action in insulin-resistant animal models are indicated.

TL;DR: Novel substituted aminopyrimidine derivatives that inhibit human GSK-3 potently with at least 500-fold selectivity against 20 other protein kinases are described and suggested to be useful as acute-acting therapeutics for the treatment of the insulin resistance of type 2 diabetes.

TL;DR: The results suggest that the differences in maximally stimulated glucose transport activity among the three fiber types may be related to differences in their content of GLUT-4 protein.

TL;DR: Angiotensin II receptor (AT1-subtype) antagonism, either acutely or chronically, improves glucose tolerance, at least in part because of an enhancement in skeletal-muscle glucose transport, and the effect of chronic angiotens in II receptor antagonism on type I skeletal-Muscle glucose uptake is associated with an increase in GLUT-4 protein expression.