Erika L. Spaeth

TL;DR: Evidence is provided that TAF are derived from mesenchymal stem cells that acquire a TAF phenotype following exposure to or systemic recruitment into adenocarcinoma xenograft models including breast, pancreatic, and ovarian and under long-term tumor conditioning in vitro, MSC express TAF–like proteins.

TL;DR: Conditions under which MSC tropism and selective engraftment in sites of inflammation can be monitored by bioluminescent imaging are identified and consistent findings were independent of tumor type, immunocompetence, and route of MSC delivery.

TL;DR: The role of inflammatory signaling in attracting MSC to tumors is discussed and radiation enhancesinflammatory signaling in the tumor microenvironment and may be used to potentiate site-specific MSC migration.

TL;DR: It is found that the timing of MSC introduction into tumors may be a critical element to safely develop MSCs as a therapeutic tool and to advance the understanding of the role of tumor stroma in carcinogenesis.

TL;DR: Through multicolored tissue transplant procedures, quantitatively determined the contribution of bone marrow-derived and adipose-derived cells to stromal populations within syngeneic ovarian and breast murine tumors.