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Erika Ziegler
Researcher at Saarland University
Publications - 5
Citations - 135
Erika Ziegler is an academic researcher from Saarland University. The author has contributed to research in topics: Dehydrogenase & Estrogen. The author has an hindex of 4, co-authored 5 publications receiving 133 citations.
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Journal ArticleDOI
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases.
Sandrine Marchais-Oberwinkler,Marie Wetzel,Erika Ziegler,Patricia Kruchten,Ruth Werth,Claudia Henn,Rolf W. Hartmann,Martin Frotscher +7 more
TL;DR: Inhibition of 17β-HSD1 inhibitors from the hydroxyphenylnaphthol class by introduction of different heteroaromatic rings as well as substituted phenyl groups showed a good membrane permeation and metabolic stability and was orally available in the rat.
Patent
17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of hormone-dependent diseases
Rolf W. Hartmann,Martin Frotscher,Sandrine Oberwinkler,Erika Ziegler,Josef Messinger,Heinrich-Hubert Thole +5 more
TL;DR: In this article, the 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) inhibitors, the production thereof, and the use thereof for treating and preventing hormone-dependent, especially estrogen-dependent or androgen-dependent diseases.
Journal ArticleDOI
Structure–activity study in the class of 6-(3′-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitors
Sandrine Marchais-Oberwinkler,Martin Frotscher,Erika Ziegler,Ruth Werth,Patricia Kruchten,Josef Messinger,Hubert Thole,Rolf W. Hartmann +7 more
TL;DR: Using a structure- and ligand-based approach, a pharmacophore model was proposed and a new class of non-steroidal inhibitors of 17beta-HSD1 was designed, and the potency of this class of inhibitors was improved by substitution of the 1-position of the naphthalene ring by a phenyl group.
Journal ArticleDOI
Development of biological assays for the identification of selective inhibitors of estradiol formation from estrone in rat liver preparations
Patricia Kruchten,Ruth Werth,Sandrine Marchais-Oberwinkler,Emmanuel Bey,Erika Ziegler,Alexander Oster,Martin Frotscher,Rolf W. Hartmann +7 more
TL;DR: Highly active and selective inhibitors of the human 17βHSD1 with promising properties for further preclinical development have been identified and the development of two assays for determination of E2-activation and -inactivation are described.
Patent
17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
Rolf W. Hartmann,Martin Frotscher,Sandrine Oberwinkler,Erika Ziegler,Josef Messinger,Heinrich-Hubert Thole +5 more
TL;DR: In this paper, the Verwendung von nicht-steroidalen 17Beta-Hydroxysteroid-Dehydrogenase-Typ 1-Inhibitoren zur Behandlung and Prophylaxe hormonabhangiger, insbesondere estrogenabhanginger Erkrankungen is investigated.