Showing papers by "Erin A. Hazlett published in 2011"
TL;DR: The preliminary findings suggest that BPD-related abnormalities in BA24 volume may occur early in the developmental course of BPD with MDD, and future studies examining samples of MDD patients with and without BPD co-morbidity will be needed to clarify whetherBA24 volume reductions are specific to BPD.
125 citations
TL;DR: Findings indicate that ventricular enlargement is globally interrelated with gray matter volume diminution but not directly correlated with volume loss in the immediately adjacent caudate, putamen, or internal capsule.
Abstract: Ventricular enlargement is one of the most consistent abnormal structural brain findings in schizophrenia and has been used to infer brain shrinkage. However, whether ventricular enlargement is related to local overlying cortex and/or adjacent subcortical structures or whether it is related to brain volume change globally has not been assessed. We systematically assessed interrelations of ventricular volumes with gray and white matter volumes of 40 Brodmann areas (BAs), the thalamus and its medial dorsal nucleus and pulvinar, the internal capsule, caudate and putamen. We acquired structural MRI ( patients with schizophrenia (n = 64) and healthy controls (n = 56)) and diffusion tensor fractional anisotropy (FA) (untreated schizophrenia n = 19, controls n = 32). Volumes were assessed by manual tracing of central structures and a semi-automated parcellation of BAs. Patients with schizophrenia had increased ventricular size associated with decreased cortical gray matter volumes widely across the brain; a similar but less pronounced pattern was seen in normal controls; local correlations (e.g. temporal horn with temporal lobe volume) were not appreciably higher than non-local correlations (e.g. temporal horn with prefrontal volume). White matter regions adjacent to the ventricles similarly did not reveal strong regional relationships. FA and center of mass of the anterior limb of the internal capsule also appeared differentially influenced by ventricular volume but findings were similarly not regional. Taken together, these findings indicate that ventricular enlargement is globally interrelated with gray matter volume diminution but not directly correlated with volume loss in the immediately adjacent caudate, putamen, or internal capsule.
62 citations
TL;DR: By delineating normal gender differences and age-related morphometric changes in the cingulate cortex over seven decades of adulthood, this study improves the baseline for comparison with structural irregularities inThe cingulates cortex associated with psychopathology.
56 citations
TL;DR: The results indicate cingulum-temporal lobe FA abnormalities in SPD and suggest that cedulum abnormalities are associated with negative symptoms.
37 citations
TL;DR: Patients ill more than three years showed lower anisotropy in frontal motor and cingulate white matter in comparison to acute patients ill three years or less, consistent with an ongoing progression of the illness.
28 citations
TL;DR: Findings suggest spatial working memory impairments may be a core neuropsychological deficit specific to SPD patients and highlight the role of VLPFC subcomponents in normal and dysfunctional memory performance.
23 citations
12 Dec 2011
TL;DR: The results suggest that schizophrenia patients may have altered blood flow-metabolic processes during neuronal activities underlying attention deficits, which may be useful for early diagnosis of schizophrenia.
Abstract: This research investigated the relationship between regional cerebral glucose metabolism rate (rGMR) of [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) and hemodynamic response of blood-oxygen-level-dependent (BOLD) fMRI in schizophrenia. An auditory prepulse-to-attention task was performed during the FDG uptake and the fMRI scan, and PET and fMRI images were obtained for 10 unmedicated schizophrenia patients and 7 healthy controls. Hemodynamic response curves were extracted from several brain regions and the area under the curve (AUC) was calculated and correlated with corresponding rGMR. The results indicated that (1) The rGMR and hemodynamic responses were significantly correlated in the frontal and temporal cortices, anterior cingulate cortex (ACC), caudate and thalamus for all subjects; (2) The patterns of the correlations are different between patients and controls. These results suggest that schizophrenia patients may have altered blood flow-metabolic processes during neuronal activities underlying attention deficits, which may be useful for early diagnosis of schizophrenia.
2 citations