E
Erin B. Purcell
Researcher at Old Dominion University
Publications - 24
Citations - 1184
Erin B. Purcell is an academic researcher from Old Dominion University. The author has contributed to research in topics: Second messenger system & Caulobacter crescentus. The author has an hindex of 13, co-authored 20 publications receiving 1018 citations. Previous affiliations of Erin B. Purcell include University of North Carolina at Chapel Hill & University of Chicago.
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Journal ArticleDOI
A photosensory two-component system regulates bacterial cell attachment
TL;DR: The differentiating bacterium, Caulobacter crescentus, contains an operon encoding a two-component signaling system consisting of a LOV-histidine kinase, LovK, and a single-domain response regulator, LovR, which results in a light-independent increase in cell–cell attachment in the lovK–lovR overexpression background.
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Cyclic diguanylate inversely regulates motility and aggregation in Clostridium difficile
TL;DR: The effect of c-di-GMP on the motility of a gram-positive bacterium and on aggregation of C. difficile cells is demonstrated, which may be relevant to the function of this signaling molecule during infection.
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Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile
Eric Bordeleau,Erin B. Purcell,Daniel A. Lafontaine,Louis-Charles Fortier,Rita Tamayo,Vincent Burrus +5 more
TL;DR: Results support a model in which T4P gene transcription is upregulated by c-di-GMP as a result of its binding to an upstream transcriptionally activating riboswitch, promoting cell aggregation in C. difficile.
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Structure of the redox sensor domain of Azotobacter vinelandii NifL at atomic resolution: signaling, dimerization, and mechanism.
TL;DR: The crystal structure of the FAD-bound PAS domain of NifL is determined and suggests a model for redox-mediated signaling in which a conformational change is initiated by red ox-dependent changes in protonation at the N5 atom of FAD that lead to reorganization of hydrogen bonds within the flavin binding pocket.
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The second messenger cyclic Di-GMP regulates Clostridium difficile toxin production by controlling expression of sigD
TL;DR: The effect of c-di-GMP on expression of the toxin genes tcdA and tcdB was determined, and the mechanism connecting flagellar and toxin gene expressions was examined, suggesting that SigD positively regulates toxin genes in C. difficile.