Erzsébet Mernyák

TL;DR: Experimental data lead to the conclusion that estrone-16-oxime ethers may be regarded as potential starting structures for the design of novel anticancer agents.

TL;DR: The inhibitory effects of the delta4-3-ketosteroids on 5alpha-reductase were studied and the structures of the new compounds were proved by IR, 1H and 13C NMR spectroscopy, using up-to-date measuring techniques such as 2D-COSY, HMQC, and HMBC.

TL;DR: Artemisinin-estrogen hybrids were for the first time both synthesized and investigated for their in vitro biological activity against malaria parasites (Plasmodium falciparum 3D7), human cytomegalovirus (HCMV), and a panel of human malignant cells of gynecological origin containing breast (MCF7, MDA-MB-231,MDAMB-361, T47D) and cervical tumor cell lines (HeLa, SiHa, C33A) as discussed by the authors.

TL;DR: An effective epimerization of the normal estrone 3-methyl and 3-benzyl ethers by using o-phenylenediamine and AcOH made the possibility for facile entry into the 13alpha-estrone series, which are estrogen receptor-selective molecules.

TL;DR: The inhibitory effects of these compounds on rat testicular C 17,20 -lyase were investigated with an in vitro radioincubation technique as discussed by the authors, and the results showed that they led to the formation of androst-5-en-3β-ols substituted in position 17β with dihydrooxazine residues.