Gyula Schneider

TL;DR: Recent studies of the synthesis of modified cardenolides which are expected to have better cardiotonic activities and of steroids with a variety of heterocycles at C-17 which have been tested against P45017 are dealt with.

TL;DR: The experimental findings on the BF(3)-catalyzed transformations were supported by calculations of the proposed mechanism at the BLYP/6-31G(d) level of theory, indicating a noteworthy dependence, mainly of the initial complexation step, and hence of the whole process, on the character of the substituent.

TL;DR: The review covers literature publications relating to the synthesis and antiproliferative activity of semisynthetic sex hormone-derived molecules containing simple or heterocyclic substituents from 2002 to 2012.

TL;DR: Various steroidal benzylidenes were synthetized from pregnenolone with benzaldehyde and p-substituted benzaldehydes, resulting in a mixture of two steroidal pyrazoline epimers which could be separated only in their acetylated form.

TL;DR: Experimental data lead to the conclusion that estrone-16-oxime ethers may be regarded as potential starting structures for the design of novel anticancer agents.