The remarkable advances in biotechnology and health sciences have led to a significant production of data, such as high throughput genetic data and clinical information, generated from large Electronic Health Records (EHRs). To this end, application of machine learning and data mining methods in biosciences is presently, more than ever before, vital and indispensable in efforts to transform intelligently all available information into valuable knowledge. Diabetes mellitus (DM) is defined as a group of metabolic disorders exerting significant pressure on human health worldwide. Extensive research in all aspects of diabetes (diagnosis, etiopathophysiology, therapy, etc.) has led to the generation of huge amounts of data. The aim of the present study is to conduct a systematic review of the applications of machine learning, data mining techniques and tools in the field of diabetes research with respect to a) Prediction and Diagnosis, b) Diabetic Complications, c) Genetic Background and Environment, and e) Health Care and Management with the first category appearing to be the most popular. A wide range of machine learning algorithms were employed. In general, 85% of those used were characterized by supervised learning approaches and 15% by unsupervised ones, and more specifically, association rules. Support vector machines (SVM) arise as the most successful and widely used algorithm. Concerning the type of data, clinical datasets were mainly used. The title applications in the selected articles project the usefulness of extracting valuable knowledge leading to new hypotheses targeting deeper understanding and further investigation in DM.

Machine Learning and Data Mining Methods in Diabetes Research.

Diabetes mellitus is a chronic disease characterized by hyperglycemia. It may cause many complications. According to the growing morbidity in recent years, in 2040, the world's diabetic patients will reach 642 million, which means that one of the ten adults in the future is suffering from diabetes. There is no doubt that this alarming figure needs great attention. With the rapid development of machine learning, machine learning has been applied to many aspects of medical health. In this study, we used decision tree, random forest and neural network to predict diabetes mellitus. The dataset is the hospital physical examination data in Luzhou, China. It contains 14 attributes. In this study, five-fold cross validation was used to examine the models. In order to verity the universal applicability of the methods, we chose some methods that have the better performance to conduct independent test experiments. We randomly selected 68994 healthy people and diabetic patients' data, respectively as training set. Due to the data unbalance, we randomly extracted 5 times data. And the result is the average of these five experiments. In this study, we used principal component analysis (PCA) and minimum redundancy maximum relevance (mRMR) to reduce the dimensionality. The results showed that prediction with random forest could reach the highest accuracy (ACC = 0.8084) when all the attributes were used.

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Predicting Diabetes Mellitus With Machine Learning Techniques.

A bearing fault diagnosis method has been proposed based on multi-scale entropy (MSE) and adaptive neuro-fuzzy inference system (ANFIS), in order to tackle the nonlinearity existing in bearing vibration as well as the uncertainty inherent in the diagnostic information. MSE refers to the calculation of entropies (e.g. appropriate entropy, sample entropy) across a sequence of scales, which takes into account not only the dynamic nonlinearity but also the interaction and coupling effects between mechanical components, thus providing much more information regarding machinery operating condition in comparison with traditional single scale-based entropy. ANFIS can benefit from the decision-making under uncertainty enabled by fuzzy logic as well as from learning and adaptation that neural networks provide. In this study, MSE and ANFIS are employed for feature extraction and fault recognition, respectively. Experiments were conducted on electrical motor bearings with three different fault categories and several levels of fault severity. The experimental results indicate that the proposed approach cannot only reliably discriminate among different fault categories, but identify the level of fault severity. Thus, the proposed approach has possibility for bearing incipient fault diagnosis.

Bearing fault diagnosis using multi-scale entropy and adaptive neuro-fuzzy inference

In this paper, a hybrid intelligent system that consists of the Fuzzy Min-Max neural network, the Classification and Regression Tree, and the Random Forest model is proposed, and its efficacy as a decision support tool for medical data classification is examined. The hybrid intelligent system aims to exploit the advantages of the constituent models and, at the same time, alleviate their limitations. It is able to learn incrementally from data samples (owing to Fuzzy Min-Max neural network), explain its predicted outputs (owing to the Classification and Regression Tree), and achieve high classification performances (owing to Random Forest). To evaluate the effectiveness of the hybrid intelligent system, three benchmark medical data sets, viz., Breast Cancer Wisconsin, Pima Indians Diabetes, and Liver Disorders from the UCI Repository of Machine Learning, are used for evaluation. A number of useful performance metrics in medical applications which include accuracy, sensitivity, specificity, as well as the area under the Receiver Operating Characteristic curve are computed. The results are analyzed and compared with those from other methods published in the literature. The experimental outcomes positively demonstrate that the hybrid intelligent system is effective in undertaking medical data classification tasks. More importantly, the hybrid intelligent system not only is able to produce good results but also to elucidate its knowledge base with a decision tree. As a result, domain users (i.e., medical practitioners) are able to comprehend the prediction given by the hybrid intelligent system; hence accepting its role as a useful medical decision support tool.

A hybrid intelligent system for medical data classification

Multi-fault classification based on wavelet SVM with PSO algorithm to analyze vibration signals from rolling element bearings

Brain tumor detection based on Convolutional Neural Network with neutrosophic expert maximum fuzzy sure entropy

In this paper, an automatic diagnosis system for diabetes on Linear Discriminant Analysis (LDA) and Morlet Wavelet Support Vector Machine Classifier: LDA-MWSVM is introduced. The structure of this automatic system based on LDA-MWSVM for the diagnosis of diabetes is composed of three stages: The feature extraction and feature reduction stage by using the Linear Discriminant Analysis (LDA) method and the classification stage by using Morlet Wavelet Support Vector Machine (MWSVM) classifier stage. The Linear Discriminant Analysis (LDA) is used to separate features variables between healthy and patient (diabetes) data in the first stage. The healthy and patient (diabetes) features obtained in the first stage are given to inputs of the MWSVM classifier in the second stage. Finally, in the third stage, the correct diagnosis performance of this automatic system based on LDA-MWSVM for the diagnosis of diabetes is calculated by using sensitivity and specificity analysis, classification accuracy, and confusion matrix, respectively. The classification accuracy of this system was obtained at about 89.74%.

An automatic diabetes diagnosis system based on LDA-Wavelet Support Vector Machine Classifier

An intelligent diagnosis system for diabetes on Linear Discriminant Analysis and Adaptive Network Based Fuzzy Inference System: LDA-ANFIS

In this study, a method based on Principle Component Analysis and Least Square Support Vector Machine Classifier for Expert Hepatitis Diagnosis System (PCA-LSSVM) is introduced. This intelligent diagnosis system deals with combination of the feature extraction and classification. This intelligent hepatitis diagnosis system is separated into two phases: (1) the feature extraction from hepatitis diseases database and feature reduction by PCA, (2) the classification by LSSVM classifier. The hepatitis diseases features were obtained from UCI Repository of Machine Learning Databases. The number of these feature attributes are 19. Then, number of these features was reduced to 10 from 19 by using PCA. In second phase, these reduced features are given to inputs LSSVM classifier. The correct diagnosis performance of the PCA-LSSVM intelligent diagnosis system for hepatitis disease is estimated by using classification accuracy, sensitivity and specifity analysis respectively.

Short communication: A new intelligent hepatitis diagnosis system: PCA-LSSVM

In this paper, an automatic diagnosis system based on Linear Discriminant Analysis (LDA) and Adaptive Network based on Fuzzy Inference System (ANFIS) for hepatitis diseases is introduced. This automatic diagnosis system deals with the combination of feature extraction and classification. This automatic hepatitis diagnosis system has two stages, which feature extraction - reduction and classification stages. In the feature extraction - reduction stage, the hepatitis features were obtained from UCI Repository of Machine Learning Databases. Then, the number of these features was reduced to 8 from 19 by using Linear Discriminant Analysis (LDA). In the classification stage, these reduced features are given to inputs ANFIS classifier. The correct diagnosis performance of the LDA-ANFIS automatic diagnosis system for hepatitis disease is estimated by using classification accuracy, sensitivity and specificity analysis, respectively. The classification accuracy of this LDA-ANFIS automatic diagnosis system for the diagnosis of hepatitis disease was obtained in about 94.16%.

Esin Dogantekin

Papers

Brain tumor detection based on Convolutional Neural Network with neutrosophic expert maximum fuzzy sure entropy

An automatic diabetes diagnosis system based on LDA-Wavelet Support Vector Machine Classifier

An intelligent diagnosis system for diabetes on Linear Discriminant Analysis and Adaptive Network Based Fuzzy Inference System: LDA-ANFIS

Short communication: A new intelligent hepatitis diagnosis system: PCA-LSSVM

Automatic hepatitis diagnosis system based on Linear Discriminant Analysis and Adaptive Network based on Fuzzy Inference System