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Esteban Saperas
Researcher at Autonomous University of Barcelona
Publications - 67
Citations - 2957
Esteban Saperas is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Mast cell & Irritable bowel syndrome. The author has an hindex of 24, co-authored 62 publications receiving 2705 citations.
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Journal ArticleDOI
Diarrhoea‐predominant IBS patients show mast cell activation and hyperplasia in the jejunum
Mar Guilarte,Javier Santos,Inés de Torres,Carmen Alonso,María Vicario,Laura Ramos,Cristina Martínez,Francesc Casellas,Esteban Saperas,Juan R. Malagelada +9 more
TL;DR: This jejunal mucosal inflammatory profile may help identify diarrhoea-predominant IBS, a stress-related disorder and upper gut symptoms were not associated with gender, mast cell counts, jeJunal tryptase or basal stress.
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A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use
Angel Lanas,Maria Ángeles Pérez-Aisa,Faust Feu,Julio Ponce,Esteban Saperas,Santos Santolaria,Luis Rodrigo,Joaquim Balanzó,Eduardo Bajador,Pedro Almela,J.M. Navarro,Fernando Carballo,Manuel Castro,Enrique Quintero +13 more
TL;DR: Mortality rates associated with either major upper or lower GI events are similar but upper GI events were more frequent and one-third of all NSAID/aspirin deaths can be attributed to low-dose aspirin use.
Journal ArticleDOI
Release of mast cell mediators into the jejunum by cold pain stress in humans
Javier Santos,Esteban Saperas,Carmen Nogueiras,Marisabel Mourelle,María Antolín,Alvaro Cadahia,Juan R. Malagelada +6 more
TL;DR: The ability of the central nervous system to modulate intestinal mast cell activity is shown and suggested that mast cells have a role in stress-related gut dysfunction.
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A multicenter, randomized, clinical trial of hormonal therapy in the prevention of rebleeding from gastrointestinal angiodysplasia
Félix Junquera,Faust Feu,Michel Papo,Sebastián Videla,Jose Ramon Armengol,Josep M. Bordas,Esteban Saperas,Josep M. Piqué,Juan-Ramon Malagelada +8 more
TL;DR: Continuous estrogen-progestagen treatment is not useful in the prevention of rebleeding from gastrointestinal angiodysplasia.
Journal ArticleDOI
The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations
Cristina Martínez,María Vicario,Laura Ramos,Beatriz Lobo,Jose Luis Mosquera,Carmen Alonso,Alex Sánchez,Mar Guilarte,María Antolín,Inés de Torres,Ana M González-Castro,Marc Pigrau,Esteban Saperas,Fernando Azpiroz,Javier Santos +14 more
TL;DR: IBS-D manifestations are linked to molecular alterations involving MC-related dysregulation of TJ functioning in the jejunal mucosa and intestinal permeability, MC biology, and TJ signaling.