Santos Santolaria

TL;DR: Coxib use presents a lower RR of UGIB than non-selective NSAIDs, however, when combined with low-dose aspirin, the differences between non-selection NSAIDs and coxibs tend to disappear.

TL;DR: Mortality rates associated with either major upper or lower GI events are similar but upper GI events were more frequent and one-third of all NSAID/aspirin deaths can be attributed to low-dose aspirin use.

TL;DR: The results show that, at least in some white populations, the contribution of the cytokine gene polymorphisms evaluated in this study to GC susceptibility may be less relevant than previously reported.

TL;DR: The clinical presentation of CI is very heterogeneous, perhaps explaining why clinical suspicion of this disease is so low and the presence of IRCI, and occurrence of peritoneal signs or onset of CI as severe abdominal pain without bleeding, should alert the physician to a potentially unfavorable course.

TL;DR: Interaction of both H. pylori infection and NSAID use decreases the risk of bleeding due to gastric ulcers, but not that due to duodenal ulcers.