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Showing papers in "The American Journal of Gastroenterology in 2005"


Journal ArticleDOI
TL;DR: In this article, the presence of biopsy-associated bacteria was detected using a nucleic acid-based method and confirmed by DNA sequencing of 16S rRNA for 6 weeks of VSL#3.

719 citations


Journal ArticleDOI
TL;DR: With these real-time PCR assays, quantitative alterations in the GI microbiota of IBS patients were found and increasing microbial DNA sequence information will further allow designing of new real- time PCR Assays for a more extensive analysis of intestinal microbes in IBS.

667 citations


Journal ArticleDOI
TL;DR: Limited histological data support an association between improved aminotransferases and biopsy findings, which require confirmation in a double-blind trial with appropriate statistical power based on liver histology.

652 citations


Journal ArticleDOI
TL;DR: Malignant gastrointestinal stromal tumors rare, but are more common in the older population, men, and Blacks, and risk factors for mortality include older age, Black race, advanced stage, and no surgical intervention.

616 citations


Journal ArticleDOI
TL;DR: CE is superior to push enteroscopy and small bowel barium radiography for diagnosing clinically significant small bowel pathology in patients with OGIB, according to a recursive literature search of prospective studies comparing the yield of CE to other modalities in patientswith OGIB.

615 citations


Journal ArticleDOI
TL;DR: Pooled results of observational studies support a protective association between 5-aminosalicylates and CRC or a combined endpoint of CRC/dysplasia in patients with ulcerative colitis.

580 citations


Journal ArticleDOI
TL;DR: Overweight and obesity are strong independent risk factor of GERD symptoms and esophageal erosions and do not appear to be a likely explanation for these findings.

531 citations


Journal ArticleDOI
TL;DR: The present meta-analysis of intestinal cancer risk in CD revealed an overall increased risk of both CRC and small bowel cancer among patients with CD, but some of the available data were several decades old, and future studies taking new treatment strategies into account are required.

518 citations


Journal ArticleDOI
TL;DR: Dyspepsia is a chronic or recurrent pain or discomfort centered in the upper abdomen; patients with predominant or frequent heartburn or acid regurgitation, should be considered to have gastroesophageal reflux disease (GERD) until proven otherwise.

504 citations


Journal ArticleDOI
TL;DR: CT evidence of a diverticular abscess has a prognostic impact as it correlates with a high risk of failure from nonoperative management regardless of the patient's age, and physicians should strongly consider elective surgery in order to prevent recurrent diverticulitis.

459 citations


Journal ArticleDOI
TL;DR: There is no evidence that constipation can successfully be treated by increasing fluid intake unless there is evidence of dehydration, and in the elderly constipation may correlate with decreased physical activity, but many cofactors are likely to play a role.

Journal ArticleDOI
TL;DR: This pilot study suggests that dietary intervention can be effective in improving histology in patients with biopsy-proven NASH, and among patients who successfully completed 1 yr of intense dietary intervention, nine of 15 patients with NASH displayed histologic improvement.

Journal ArticleDOI
TL;DR: There is good evidence to support the use of PEG, tegaserod, lactulose, and psyllium and recommendations were made regarding their use following the United States Preventive Services Task Force guidelines.

Journal ArticleDOI
TL;DR: The simpler, cheaper, and more easily used NG feeding is as good as NJ feeding in patients with objectively graded severe AP, and appears to be a useful and practical therapeutic approach to enteral feeding in the early management of patients with severe AP.

Journal ArticleDOI
TL;DR: Data suggest that Klebsiella liver abscess may represent an emerging disease in Western countries, such as the United States, and appropriate antibiotic therapy and a diagnostic work-up for metastatic complications should be employed.

Journal ArticleDOI
TL;DR: Current evidence suggests that the initial insult to the esophagus results in myenteric plexus inflammation, which leads to an autoimmune response in a susceptible population who may be genetically predisposed to achalasia.

Journal ArticleDOI
TL;DR: Mortality rates associated with either major upper or lower GI events are similar but upper GI events were more frequent and one-third of all NSAID/aspirin deaths can be attributed to low-dose aspirin use.

Journal ArticleDOI
TL;DR: Recurrent abdominal pain of childhood is a common complaint of childhood with associated familial, psychological, and co-morbid conditions, and Epidemiologic studies of RAP in children may offer information on the evolution of functional bowel disorders through the lifespan.

Journal ArticleDOI
TL;DR: The purpose of this review is to characterize the clinical and pathological features of these syndromes and to review the targets of cancer surveillance.

Journal ArticleDOI
TL;DR: PDT is minimally invasive but shows a considerable postinterventional cholangitis rate and has the potential to result in a changeover of current palliative treatment of BDC.

Journal ArticleDOI
TL;DR: Immunization against selected vaccine-preventable illnesses was uncommon in patients with IBD, despite the presence of significant risk factors.

Journal ArticleDOI
TL;DR: The high incidence and younger age at presentation of colorectal cancer in African Americans warrant initiation of colorsight screening at the age 45 yr rather than 50 yr, and clinical gastroenterologists should play an active role in educating the public and primary care physicians about special issues surrounding coloreCTal cancer.

Journal ArticleDOI
TL;DR: Although urgent Colonoscopy identified a definite source of LGIB more often than a standard care algorithm based on angiography and expectant colonoscopy, the approaches are not significantly different with regard to important outcomes.

Journal ArticleDOI
TL;DR: A systematic review on the Management of Chronic Constipation in North America Lawrence J. Brandt, M.D., M.A.C.P., F.R.CC.G.P, and Philip Schoenfeld of the National University of Ireland's Gastroenterology and Hepatology Center finds that chronic constipation is a major cause of disability in women in the United States.

Journal ArticleDOI
TL;DR: Although the status of intestinal microflora in the irritable bowel syndrome remains unsettled, small intestinal bacterial overgrowth and increased fermentation of foods with gas production, provide indirect evidence that micro Flora may contribute to symptom generation in irritable intestine syndrome.

Journal ArticleDOI
TL;DR: Patients with moderately active ulcerative colitis treated with 4.8 g/day of mesalamine (800 mg tablet) are significantly more likely to achieve overall improvement at 6 wk compared to patients treated with 2.4 g/ day, and both regimens were well tolerated.

Journal ArticleDOI
TL;DR: The results concerning correlations suggest that disturbances in BMI, body fat, and lipid metabolism may contribute to altered oxidative status in NAFLD, and insulin resistance may be related to decreased antioxidants inNAFLD as well as products of lipid peroxidation.

Journal ArticleDOI
TL;DR: Based on “in depth” evidence presented at this workshop, the majority of the scientific task force favored a search-and-treat strategy in first-degree relatives of gastric cancer patients and an overwhelming majority felt that a more general screen- and-t treat strategy should be focused in the first instance on a population with a high incidence of H. pylori-associated diseases.

Journal ArticleDOI
TL;DR: Evidence to support the use of blood tests, radiography, or endoscopy in the routine work up of patients with constipation without alarm features is lacking and large, well-designed, prospective studies are required to examine the utility of these tests.

Journal ArticleDOI
TL;DR: Dilation of intercellular spaces is a feature of NERD patients, irrespective of esophageal acid exposure, and can be considered an objective, structural marker of GERD symptoms.