Eun Sang Choe

TL;DR: The proposed glutamate microbiosensor was successfully used for in vivo monitoring of the extracellular glutamate released by cocaine stimulation and was completely minimized by coimmobilizing ascorbate oxidase and coating the sensor surface with a cationic polymer, polyethyleneimine.

TL;DR: Emerging evidence shows that as a rapid and short-term mechanism, the dynamic protein phosphorylation directly modulates the electrophysiological, morphological, and biochemical properties of the AMPA receptor, as well as protein-protein interactions between theAMPA receptor subunits and various intracellular interacting proteins.

TL;DR: A novel, mGLUR5-triggered signaling mechanism involving use- and Src-dependent inactivation of PP2A, which contributes to mGluR5 activation of MEK1/2 and ERK1 /2 is identified.

TL;DR: The concentrations of NO levels by acute and repeated injections of cocaine were determined to be 1.13+/-0.03 and 2.05 microM, respectively, showing high sensitivity of the microbiosensor in monitoring NO concentrations in the in vivo intact brain.

TL;DR: The data suggest that protein phosphatase 1/2A in striatal neurons is tonically active in dephosphorylating CREB and Elk‐1 and thus suppressing constitutive c‐fos mRNA and protein expression.