N
Nikhil K. Parelkar
Researcher at University of Kansas
Publications - 28
Citations - 1056
Nikhil K. Parelkar is an academic researcher from University of Kansas. The author has contributed to research in topics: Metabotropic glutamate receptor & Nucleus accumbens. The author has an hindex of 16, co-authored 28 publications receiving 987 citations. Previous affiliations of Nikhil K. Parelkar include University of Missouri–Kansas City.
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Journal ArticleDOI
Modulation of D2R-NR2B Interactions in Response to Cocaine
Xian-Yu Liu,Xiang-Ping Chu,Limin Mao,Min Wang,Hong Xiang Lan,Minghua Li,Guo Chi Zhang,Nikhil K. Parelkar,Eugene E. Fibuch,Michelle Haines,Kim A. Neve,Fang Liu,Zhi-Gang Xiong,John Q. Wang +13 more
TL;DR: Dopamine-glutamate interactions in the neostriatum determine psychostimulant action, but the underlying molecular mechanisms remain elusive and a direct and dynamic D2R-NR2B interaction in striatal neurons in vivo is uncovered.
Journal ArticleDOI
Phosphorylation of AMPA receptors: mechanisms and synaptic plasticity.
John Q. Wang,Anish Arora,Lu Yang,Nikhil K. Parelkar,Guochi Zhang,Xian-Yu Liu,Eun Sang Choe,Limin Mao +7 more
TL;DR: Emerging evidence shows that as a rapid and short-term mechanism, the dynamic protein phosphorylation directly modulates the electrophysiological, morphological, and biochemical properties of the AMPA receptor, as well as protein-protein interactions between theAMPA receptor subunits and various intracellular interacting proteins.
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Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity.
John Q. Wang,Qingsong Tang,Nikhil K. Parelkar,Zhenguo Liu,Shazia Samdani,Eun Sang Choe,Lu Yang,Limin Mao +7 more
TL;DR: Emerging evidence shows that MAPK-mediated genomic responses in striatal neurons to drug exposure contribute to the development of neuroplasticity related to addictive properties of drugs of abuse.
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In Vivo Regulation of Homer1a Expression in the Striatum by Cocaine
Guo Chi Zhang,Limin Mao,Xian-Yu Liu,Nikhil K. Parelkar,Anish Arora,Lu Yang,Michelle Hains,Eugene E. Fibuch,John Q. Wang +8 more
TL;DR: The results indicate that cocaine possesses the ability to stimulate Homer1a expression in striatal neurons through a specific synapse-to-nucleus pathway and may represent a transcription-dependent mechanism underlying the dynamic regulation of submembranous macromolecular complex formation between group I mGluRs and their anchoring proteins.
Journal ArticleDOI
Phosphorylation of glutamate receptors: a potential mechanism for the regulation of receptor function and psychostimulant action.
John Q. Wang,Xian-Yu Liu,Guochi Zhang,Nikhil K. Parelkar,Anish Arora,Michelle Haines,Eugene E. Fibuch,Limin Mao +7 more
TL;DR: Emerging evidence shows that psychostimulants may modulate NMDAR and AMPAR function through the phosphorylation mechanism to shape the excitatory synaptic plasticity related to additive properties of drugs of abuse.