E
Eva J. Helmerhorst
Researcher at Boston University
Publications - 90
Citations - 5686
Eva J. Helmerhorst is an academic researcher from Boston University. The author has contributed to research in topics: Histatin & Saliva. The author has an hindex of 41, co-authored 90 publications receiving 5236 citations. Previous affiliations of Eva J. Helmerhorst include Harvard University & Boston Medical Center.
Papers
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Journal ArticleDOI
Identification of early microbial colonizers in human dental biofilm
J. Li,Eva J. Helmerhorst,Leone Cw,Robert F. Troxler,Tina Yaskell,A. D. Haffajee,Sigmund S. Socransky,Frank G. Oppenheim +7 more
TL;DR: The first colonizers within in vivo dental biofilm are elucidated and potential population shifts that occur during the early phases of biofilm formation are established.
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Antimicrobial peptides: properties and applicability.
TL;DR: In this article, a review of the functional and structural features of naturally occurring antimicrobial peptides and their potential as therapeutics is presented. But the focus is not on the adaptive immune system, with its network of humoral and cellular responses is only found in higher animals, while innate immunity is encountered in all living creatures.
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Saliva: a Dynamic Proteome
TL;DR: Understanding the proteome of whole saliva in an environment of continuous turnover will be a prerequisite to gain insight into the physiological and pathological processes relevant to oral health, and be crucial for the identification of meaningful biomarkers for oral disease.
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The Cellular Target of Histatin 5 on Candida albicans Is the Energized Mitochondrion
Eva J. Helmerhorst,Pieter Breeuwer,Wim van 't Hof,E. Walgreen-Weterings,L. C. J. M. Oomen,Enno C. I. Veerman,Arie V. Nieuw Amerongen,Tjakko Abee +7 more
TL;DR: Data indicate that histatin 5 is internalized, and targets to the energized mitochondrion, like the biological effects, which was inhibited by mitochondrial inhibitors and high salt conditions.
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The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species
TL;DR: Data provide strong evidence for a comprehensive mechanistic model of histatin-5-provoked yeast cell death in which oxygen radical formation is the ultimate and essential step.