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Evgeniy Yablokov
Researcher at Institute of Business & Medical Careers
Publications - 8
Citations - 76
Evgeniy Yablokov is an academic researcher from Institute of Business & Medical Careers. The author has contributed to research in topics: Prostacyclin & Prostacyclin synthase. The author has an hindex of 3, co-authored 8 publications receiving 35 citations.
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Journal ArticleDOI
SPR Biosensors in Direct Molecular Fishing: Implications for Protein Interactomics
A. V. Florinskaya,P V Ershov,Yuri Mezentsev,L. A. Kaluzhskiy,Evgeniy Yablokov,Alexei Medvedev,A. S. Ivanov +6 more
TL;DR: An original experimental approach based on the use of surface plasmon resonance (SPR) biosensors, applicable for investigation of potential partners involved in protein–protein interactions (PPI) as well as protein–peptide or protein–small molecule interactions.
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A large-scale comparative analysis of affinity, thermodynamics and functional characteristics of interactions of twelve cytochrome P450 isoforms and their redox partners.
Evgeniy Yablokov,T. A. Sushko,P V Ershov,A. V. Florinskaya,Oksana Gnedenko,T. V. Shkel,Irina Grabovec,Natallia Strushkevich,L. A. Kaluzhskiy,Sergey A. Usanov,Andrei A. Gilep,A. S. Ivanov +11 more
TL;DR: The evolutionary point of view, the type 1 electron transport system (mitCYPs, Adx and NADPH-dependent adrenodoxin reductase (AdR)) increased the specialization of protein-protein interactions (PPI) significantly, which was accompanied by an increase in the specificity of electron transfer.
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Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context
TL;DR: In this paper, the authors present a systematization and bioinformatic analysis of the available interactomics data on seventeen enzymes in the cholesterol pathway, encoded by HMGCR, MVK, PMVK, MVD, FDPS, FDFT1, SQLE, LSS, DHCR24, CYP51A1, TM7SF2, MSMO1, NSDHL, HSD17B7, EBP, SC5D, DH CR7 genes.
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Affinity Isolation and Mass Spectrometry Identification of Prostacyclin Synthase (PTGIS) Subinteractome
P V Ershov,Yuri Mezentsev,Arthur T. Kopylov,Evgeniy Yablokov,A V Svirid,Aliaksandr Ya. Lushchyk,L. A. Kaluzhskiy,A. A. Gilep,S A Usanov,Alexey E. Medvedev,A. S. Ivanov +10 more
TL;DR: PTGIS interacted with full-length cytochrome P450 2J2 and glutathione S-transferase (GST), and was shown to bind synthetic peptides corresponding to sequences of for GSTA1, GSTM1, aldo-keto reductase (AKR1A1), glutaredoxin 3 (GLRX3) and histidine triad nucleotide binding protein 2 (HINT2).
Journal ArticleDOI
Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3'-Disulfate
L. A. Kaluzhskiy,P V Ershov,Evgeniy Yablokov,T. V. Shkel,Irina Grabovec,Yuri Mezentsev,Oksana Gnedenko,Sergey A. Usanov,Polina Shabunya,Sviatlana Fatykhava,Andrey Popov,Artyukov Aleksandr A,Olga Styshova,Andrei A. Gilep,Natallia Strushkevich,Andrew Ivanov +15 more
TL;DR: In this article, a natural flavonoid, luteolin 7,3'-disulfate, was shown to inhibit the activity of human CYP51A1 using both a surface plasmon resonance optical biosensor and spectral titration assays.