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Ewa Harasim
Researcher at Medical University of Białystok
Publications - 18
Citations - 396
Ewa Harasim is an academic researcher from Medical University of Białystok. The author has contributed to research in topics: Insulin resistance & Insulin. The author has an hindex of 12, co-authored 18 publications receiving 341 citations.
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Journal ArticleDOI
High fat diet induces ceramide and sphingomyelin formation in rat's liver nuclei.
Grzegorz Chocian,Adrian Chabowski,Małgorzata Żendzian-Piotrowska,Ewa Harasim,Bartłomiej Łukaszuk,Jan Górski +5 more
TL;DR: The findings support the conclusion that HFD has a major impact on sphingolipid metabolism not only in the liver, but also in hepatic nuclei.
Journal ArticleDOI
New evidence for the role of ceramide in the development of hepatic insulin resistance.
TL;DR: Increase in intarcellular ceramide content contributes to the development of hepatic insulin resistance and is suggested to be pivotal role of transporters in facilitating fatty acid influx, accumulation of ceramides and export to the media.
Journal ArticleDOI
Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats
Arend Bonen,Swati S. Jain,Laelie A. Snook,Xiao-Xia Han,Yuko Yoshida,Kathryn H. Buddo,James S. V. Lally,Elizabeth D. Pask,Sabina Paglialunga,Marie-Soleil Beaudoin,Jan F. C. Glatz,Joost J. F. P. Luiken,Ewa Harasim,David C. Wright,Adrian Chabowski,Graham P. Holloway +15 more
TL;DR: High-fat feeding rapidly increases intramyocellular lipids (in 2–3 days) via insulin-mediated upregulation of sarcolemmal FAT/CD36 and fatty acid transport, and the 16–19 day delay in the onset of insulin resistance suggests that additional mechanisms besides intramycellularlipids contribute to this pathology.
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Restoration of skeletal muscle leptin response does not precede the exercise induced recovery of insulin stimulated glucose uptake in high-fat fed rats
Ian R. W. Ritchie,Roberto A. Gulli,Leslie E. Stefanyk,Ewa Harasim,Adrian Chabowski,David J. Dyck +5 more
TL;DR: In conclusion, endurance exercise training is able to restore leptin response, but this does not appear to be a necessary precursor for the restoration of insulin response.
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Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation.
Marcin Baranowski,Piotr Zabielski,Agnieszka Blachnio-Zabielska,Ewa Harasim,Adrian Chabowski,Jan Górski +5 more
TL;DR: Improvement in muscle insulin sensitivity is concluded to be one of the mechanisms underlying the antidiabetic action of LXR activators.