J
Jan Górski
Researcher at Medical University of Białystok
Publications - 157
Citations - 4270
Jan Górski is an academic researcher from Medical University of Białystok. The author has contributed to research in topics: Ceramide & Insulin resistance. The author has an hindex of 33, co-authored 156 publications receiving 3860 citations. Previous affiliations of Jan Górski include University of Białystok.
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Journal ArticleDOI
Relationship Between Insulin Sensitivity and Sphingomyelin Signaling Pathway in Human Skeletal Muscle
Marek Straczkowski,Irina Kowalska,Agnieszka Nikolajuk,Stella Dzienis-Straczkowska,Ida Kinalska,Marcin Baranowski,Malgorzata Zendzian-Piotrowska,Brzezińska Z,Jan Górski +8 more
TL;DR: The data indicate that the sphingomyelin signaling pathway in muscle might be an important factor determining the development of insulin resistance in humans and to evaluate their relationships with insulin sensitivity.
Journal ArticleDOI
Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes
Marek Straczkowski,Irina Kowalska,Marcin Baranowski,Agnieszka Nikolajuk,Elzbieta Otziomek,Piotr Zabielski,Agnieszka Adamska,A. Blachnio,Jan Górski,Maria Gorska +9 more
TL;DR: Lean offspring of diabetic patients and the men with overweight or obesity showed lower insulin sensitivity and a greater muscle ceramide level and neutral sphingomyelinase activity was higher than in the obese-IGT group.
Journal ArticleDOI
n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet
Ondrej Kuda,Tomas Jelenik,Zuzana Macek Jilkova,Pavel Flachs,Martin Rossmeisl,M Hensler,Ludmila Kazdova,NC Ogston,Marcin Baranowski,Jan Górski,Petra Janovska,Vladimir Kus,Jan Polak,Vidya Mohamed-Ali,Rémy Burcelin,Saverio Cinti,Morten Bryhn,Jan Kopecky +17 more
TL;DR: DHA/EPA and rosiglitazone can be used as complementary therapies to counteract dyslipidaemia and insulin resistance and the combination treatment may reduce dose requirements and hence the incidence of adverse side effects of thiazolidinedione therapy.
Journal ArticleDOI
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
Mette Skovbro,Marcin Baranowski,C. Skov-Jensen,Anne Flint,Flemming Dela,Jan Górski,Jørn Wulff Helge +6 more
TL;DR: Total muscle ceramide content was similar between individuals showing marked differences in insulin sensitivity, and therefore does not seem to be a major factor in muscle insulin resistance, and aerobic capacity does not appear to influence muscle Ceramide content.
Journal ArticleDOI
Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease
Krzysztof Kurek,Dominika M. Piotrowska,Patrycja Wiesiołek-Kurek,Bartłomiej Łukaszuk,Adrian Chabowski,Jan Górski,Malgorzata Zendzian-Piotrowska +6 more
TL;DR: This work examined whether inhibition of ceramide de novo synthesis with myriocin ameliorate hepatic lipid accumulation and reverse NAFLD.