Ezekiel Mupere

TL;DR: There is a critical need for research on childhood tuberculosis, specifically on how nutritional status affects the risk and progression of tuberculosis and whether nutritional supplementation improves clinical outcomes or prevents disease.

TL;DR: Viral suppression was associated with GFR improvements in those with both low CD4 cell counts and impaired baseline renal function, supporting an independent contribution of HIV-1 replication to chronic renal dysfunction in advanced HIV disease.

TL;DR: The results suggest that targeting tuberculosis prevention efforts to household contacts is highly effective, however, a large proportion of transmission at the population level may occur outside the household.

TL;DR: In the Kawempe Community Health Study, 872 culture-confirmed pulmonary TB cases and their 2,585 contacts were enrolled during 2002-2012 and followed for up to 2 years each, and risk factors for progression from exposure to infection and disease differ among children, women, and men.

TL;DR: In this paper, the yield of contact tracing on childhood tuberculosis and indicators for disease progression in Uganda was assessed in one of the largest pediatric tuberculosis contact investigation studies in a resource-limited setting, and the results indicated that contact tracing for children in high-burden settings is able to identify a large percentage of culture-confirmed positive tuberculosis cases before dissemination of disease.