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Bonnie Thiel
Researcher at Case Western Reserve University
Publications - 59
Citations - 4140
Bonnie Thiel is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 29, co-authored 54 publications receiving 3719 citations. Previous affiliations of Bonnie Thiel include Makerere University & University of Michigan.
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Journal ArticleDOI
A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
Daniel E. Zak,Adam Penn-Nicholson,Thomas J. Scriba,Ethan G. Thompson,Sara Suliman,Lynn M. Amon,Hassan Mahomed,Mzwandile Erasmus,Wendy Whatney,Gregory D. Hussey,Deborah Abrahams,Fazlin Kafaar,Tony Hawkridge,Suzanne Verver,E. Jane Hughes,Martin O. C. Ota,Jayne S. Sutherland,Rawleigh Howe,Hazel M. Dockrell,W. Henry Boom,Bonnie Thiel,Tom H. M. Ottenhoff,Harriet Mayanja-Kizza,Amelia C. Crampin,Katrina Downing,Mark Hatherill,Joe Valvo,Smitha Shankar,Shreemanta K. Parida,Stefan H. E. Kaufmann,Gerhard Walzl,Alan Aderem,Willem A. Hanekom +32 more
TL;DR: The whole blood tuberculosis risk signature prospectively identified people at risk of developing active tuberculosis, opening the possibility for targeted intervention to prevent the disease.
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Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.
TL;DR: The ability of heme, tetrahydrobiopterin, and L-arginine to promote subunit dimerization is unprecedented and suggests novel roles for these molecules in forming and stabilizing the active dimeric NOS.
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Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease
Misha Angrist,Stacey Bolk,Bonnie Thiel,Erik G. Puffenberger,Robert Hofstra,Charles H.C.M. Buys,Daniel T. Cass,Aravinda Chakravarti +7 more
TL;DR: The data suggest that the overall frequency of RET mutations in HSCR patients is low and therefore, other genetic and/or environmental determinants contribute to the majority of HscR susceptibility, and at present, there is no obvious relationship between RET genotype and H SCR phenotype.
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The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo
TL;DR: An induced mutation is characterized, called embryonic ectoderm development or eed, that disrupts A-P patterning of the mouse embryo during gastrulation and is the highly conserved homologue of the Drosophila gene extra sex combs, which is required for maintenance of long-term transcriptional repression of homeotic gene expression.
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Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis
Sara Suliman,Ethan G. Thompson,Jayne S. Sutherland,January Weiner rd,Martin O. C. Ota,Smitha Shankar,Adam Penn-Nicholson,Adam Penn-Nicholson,Bonnie Thiel,Mzwandile Erasmus,Mzwandile Erasmus,Jeroen Maertzdorf,Fergal J. Duffy,Philip C. Hill,E. Jane Hughes,E. Jane Hughes,Kim Stanley,Katrina Downing,Katrina Downing,Michelle Fisher,Michelle Fisher,Joe Valvo,Shreemanta K. Parida,Gian D. van der Spuy,Gian D. van der Spuy,Gerard Tromp,Gerard Tromp,Ifedayo M. O. Adetifa,Simon Donkor,Rawleigh Howe,Harriet Mayanja-Kizza,W. Henry Boom,Hazel M. Dockrell,Tom H. M. Ottenhoff,Mark Hatherill,Mark Hatherill,Alan Aderem,Willem A. Hanekom,Willem A. Hanekom,Thomas J. Scriba,Thomas J. Scriba,Stefan H. E. Kaufmann,Daniel E. Zak,Gerhard Walzl,Gerhard Walzl +44 more
TL;DR: A simple whole blood‐based PCR test to predict TB in recently exposed household contacts from diverse African populations has potential for implementation in national TB contact investigation programs.