F
F. J. Kezdy
Researcher at Oklahoma Medical Research Foundation
Publications - 2
Citations - 196
F. J. Kezdy is an academic researcher from Oklahoma Medical Research Foundation. The author has contributed to research in topics: Active site & Substrate (chemistry). The author has an hindex of 2, co-authored 2 publications receiving 188 citations.
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Kinetic studies of human immunodeficiency virus type 1 protease and its active-site hydrogen bond mutant A28S.
TL;DR: The lowering of pK values in mutant HIV-1 protease indicates that the hydroxyl group of Ser28 forms a new hydrogen bond to active-site Asp25 to increase its acidity.
Journal ArticleDOI
pH dependence of kinetic parameters of pepsin, rhizopuspepsin, and their active-site hydrogen bond mutants.
TL;DR: For both pepsin and rhizopuspepsin, the removal of hydrogen bonds to the active-site carboxyls by mutagenesis results in negligible changes in the four pK alpha values, which suggest that these hydrogen bondsTo contribute little to the pH-activity relationships of the aspartic proteases